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LetterImaging

The Utility of Adding a Liquid-Nutrient Meal to Aid Interpretation of Small-Bowel Transit Scintigraphy

Alexandra Selby, Ho-Man Yeung, Daohai Yu, Alyssa Goldbach, Xiaoning Lu, Henry P. Parkman, Bhishak Kamat, Alan H. Maurer and Simin Dadparvar
Journal of Nuclear Medicine Technology June 2021, 49 (2) 132-137; DOI: https://doi.org/10.2967/jnmt.120.255091
Alexandra Selby
1Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania;
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Ho-Man Yeung
1Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania;
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Daohai Yu
2Department of Clinical Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania;
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Alyssa Goldbach
3Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania; and
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Xiaoning Lu
2Department of Clinical Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania;
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Henry P. Parkman
4Department of Gastroenterology, Temple University Hospital, Philadelphia, Pennsylvania
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Bhishak Kamat
3Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania; and
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Alan H. Maurer
3Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania; and
4Department of Gastroenterology, Temple University Hospital, Philadelphia, Pennsylvania
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Simin Dadparvar
3Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania; and
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  • FIGURE 1.
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    FIGURE 1.

    A 20-y-old man with nausea and vomiting who underwent sequential gastric emptying imaging, which showed normal small-bowel transit. There was normal progressive filling of TIR (single arrows) and then early progression into cecum and colon (double arrows) (anterior views). More than 40% of total activity had progressed from TIR into colon by 360 min.

  • FIGURE 2.
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    FIGURE 2.

    A 30-y-old man with nausea, vomiting, abdominal pain, and weight loss who underwent SBTS and was found to have delayed or abnormal small-bowel transit (anterior views). In contrast to patient in Figure 1, there was persistent and diffuse activity within loops of proximal small bowel and no accumulation of activity in TIR (arrows) by 360 min. There was no change in pattern of more proximal loops of small bowel after administration of LNM.

  • FIGURE 3.
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    FIGURE 3.

    A 27-y-old woman with nausea, diarrhea, bloating, and abdominal distention who had equivocal SBTS findings but confirmation of TIR and colon localization after administration of LNM (anterior views). There was progression of activity into right lower quadrant, but it was unclear whether this finding represented filling of TIR by 360 min (single arrow). After LNM, however, anatomy was more clearly defined, showing normal progression of activity from TIR into colon (double arrows).

  • FIGURE 4.
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    FIGURE 4.

    A 17-y-old boy with abdominal pain and early satiety who had equivocal SBTS findings at 6 h (anterior views). Although there was accumulation of activity in right lower quadrant at 6 h (arrow), this activity did not clearly progress into cecum or ascending colon after LNM. A 24-h image, however, helped to better define anatomy and showed that site of buildup in right lower quadrant (arrow) was in TIR, with progression of activity into ascending, transverse, and descending colon, confirming normal small-bowel transit.

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    TABLE 1

    Patient Demographics and Clinical Information

    Baseline characteristicData
    Median age (y)42 (range, 17–81)
    Sex
     Male33 (28.2)
     Female84 (71.8)
    Race
     White98 (83.8)
     Black8 (6.8)
     Hispanic10 (8.5)
     Mixed1 (0.9)
    Body mass index
     ≤1915 (12.8)
     20–2432 (27.4)
     25–2937 (31.6)
     ≥3033 (28.2)
    Symptoms
     Nausea94 (80.3)
     Vomiting76 (65.0)
     Abdominal pain47 (40.2)
     Early satiety42 (35.9)
     Weight loss29 (24.8)
     Bloating/distention38 (32.5)
     Diarrhea30 (25.6)
     Constipation15 (12.8)
     Decreased appetite/anorexia9 (7.7)
     Belching6 (5.1)
    Diagnosis
     Gastroparesis63 (53.8)
     Cyclic vomiting syndrome8 (6.8)
     IBS10 (8.5)
     SIBO32 (27.4)
     Malignancy1 (0.9)
     GERD16 (13.7)
     Dumping syndrome1 (0.9)
     Unspecified17 (14.5)
    • SIBO = small intestinal bacterial overgrowth; GERD = gastroesophageal reflux disease.

    • Except for age, data are numbers followed by percentage in parentheses; n = 117 patients total.

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    TABLE 2

    SBTS Results Before and After Administration of LNM

    ResultBefore LNMAfter LNM
    Definitive80 (68.4)105 (89.7)
     Normal58 (49.6)74 (63.2)
     Abnormal22 (18.8)31 (26.5)
    Equivocal37 (31.6)12 (10.3)
    • Data are numbers followed by percentage in parentheses; n = 117 patients total.

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    TABLE 3

    Comparison of Baseline Characteristics Between Equivocal Cases That Showed Definitive Result After LNM and Those That Remained Equivocal

    CharacteristicAll (n = 36)Definitive (n = 25)Equivocal (n = 11)P
    Median age (y)40 (range, 19–70)40 (range, 19–70)35 (range, 20–69)0.52
    Sex
     Male6 (17)5 (20)1 (9.1)0.64
     Female30 (83)20 (80)10 (91)
    Race
     White29 (81)21 (84)8 (73)0.096
     Black3 (8.3)3 (12)0 (0.0)
     Hispanic3 (8.3)1 (4.0)2 (18)
     Mixed1 (2.8)0 (0.0)1 (9.1)
    Body mass index
     ≤196 (17)5 (20)1 (9.1)0.70
     20–2411 (31)6 (24)5 (45.5)
     25–298 (22)6 (24)2 (18.2)
     ≥3011 (31)8 (32)3 (27.3)
    Symptoms
     Nausea32 (89)22 (88)10 (91)1.00
     Vomiting24 (67)17 (68)7 (64)1.00
     Abdominal pain13 (36)9 (36)4 (36)1.00
     Early satiety12 (33)11 (44)1 (9.1)0.059
     Weight loss8 (22)4 (16)4 (36)0.21
     Bloating/distention8 (22)5 (20)3 (27)0.68
     Diarrhea9 (25)6 (24)3 (27)1.00
    Constipation3 (8.3)2 (8.0)1 (9.1)1.00
     Decreased appetite/anorexia4 (11)3 (12)1 (9.1)1.00
     Belching1 (2.8)1 (4.0)0 (0.0)1.00
    Diagnosis
    Gastroparesis23 (64)13 (52)10 (91)0.031
     Cyclic vomiting syndrome2 (5.6)2 (8.0)0 (0.0)1.00
     IBS3 (8.3)0 (0.0)3 (27)0.023
     SIBO5 (14)3 (12)2 (18)0.63
     Malignancy0 (0.0)0 (0.0)0 (0.0)0.63
     GERD5 (14)5 (20)0 (0.0)0.30
     Dumping syndrome1 (2.8)0 (0.0)1 (9.1)0.31
     Unspecified5 (14)5 (20)0 (0.0)0.30
    • SIBO = small intestinal bacterial overgrowth; GERD = gastroesophageal reflux disease.

    • Except for age, data are numbers followed by percentage in parentheses; n = 36 patients total.

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Journal of Nuclear Medicine Technology: 49 (2)
Journal of Nuclear Medicine Technology
Vol. 49, Issue 2
June 1, 2021
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The Utility of Adding a Liquid-Nutrient Meal to Aid Interpretation of Small-Bowel Transit Scintigraphy
Alexandra Selby, Ho-Man Yeung, Daohai Yu, Alyssa Goldbach, Xiaoning Lu, Henry P. Parkman, Bhishak Kamat, Alan H. Maurer, Simin Dadparvar
Journal of Nuclear Medicine Technology Jun 2021, 49 (2) 132-137; DOI: 10.2967/jnmt.120.255091

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The Utility of Adding a Liquid-Nutrient Meal to Aid Interpretation of Small-Bowel Transit Scintigraphy
Alexandra Selby, Ho-Man Yeung, Daohai Yu, Alyssa Goldbach, Xiaoning Lu, Henry P. Parkman, Bhishak Kamat, Alan H. Maurer, Simin Dadparvar
Journal of Nuclear Medicine Technology Jun 2021, 49 (2) 132-137; DOI: 10.2967/jnmt.120.255091
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Keywords

  • small-bowel transit scintigraphy
  • liquid-nutrient meal
  • gastrointestinal dysmotility
  • gastroparesis
  • irritable bowel syndrome
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