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Research ArticleImaging

Evaluation of a Correction Method for 111In-Pentetreotide SPECT Imaging of Gastroenteropancreatic Neuroendocrine Tumors

Takao Kanzaki, Yasuyuki Takahashi, Tetsuya Higuchi, Xieyi Zhang, Nao Mogi, Takayuki Suto and Yoshito Tsushima
Journal of Nuclear Medicine Technology December 2020, 48 (4) 326-330; DOI: https://doi.org/10.2967/jnmt.120.249680
Takao Kanzaki
1Department of Radiology, Gunma University Hospital, Gunma, Japan
2Department of Nuclear Medicine Technology, Hirosaki University Graduate School of Health Sciences, Aomori, Japan
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Yasuyuki Takahashi
2Department of Nuclear Medicine Technology, Hirosaki University Graduate School of Health Sciences, Aomori, Japan
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Tetsuya Higuchi
3Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Gunma, Japan; and
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Xieyi Zhang
4Laboratory of Biopharmaceutics, Department of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Gunma, Japan
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Nao Mogi
1Department of Radiology, Gunma University Hospital, Gunma, Japan
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Takayuki Suto
1Department of Radiology, Gunma University Hospital, Gunma, Japan
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Yoshito Tsushima
3Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Gunma, Japan; and
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  • FIGURE 1.
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    FIGURE 1.

    Comparison of SPECT QA (JS-10) phantom images for EWW, image reconstruction conditions, and CT images and of anthropomorphic abdominal (LKS) phantom for image collection conditions.

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    FIGURE 2.

    CNR of hot rods for optimum EWW in phantom study. EWW setting of 171 keV ± 10% and 245 keV ± 7.5% was significantly better than other settings (P < 0.05).

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    FIGURE 3.

    Optimization of OSEM technique between CNR and numbers of iterations in phantom study. OSEM reconstruction conditions of 8 subsets and 6 iterations gave significantly highest CNR (P < 0.05).

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    FIGURE 4.

    Comparison of 4 techniques of SPECT image correction (NC, SC, AC, and CC) in phantom study. Although underestimation occurred in pancreas when NC and SC were used, CC showed no significant difference (P = 0.83). In particular, CC gave significantly better CNR for pancreas than did NC or SC (P < 0.05).

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    FIGURE 5.

    Axial phantom SPECT images corrected by 4 methods (NC, SC, AC, and CC).

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    FIGURE 6.

    Box plot of CNR evaluated by 4 methods (NC, SC, AC, and CC) in 20 GEP NET patients. NC and SC showed no significant difference (P = 0.86), whereas CC showed significant differences from NC and SC.

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    FIGURE 7.

    Case of G1 NET of pancreatic head without metastasis. (A) Highly enhanced lesion (arrow) in pancreas is noted in early dynamic MR image. (B) 111In-pentetreotide SPECT images with NC, SC, AC, and CC depict abnormal uptake in corresponding upper abdominal area (arrows). Although images with SC and AC show comparable visualization of lesion with NC, CC delineates lesion most clearly.

Tables

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    TABLE 1

    Patient Characteristics

    CharacteristicData
    Age (y)66.0 ± 15.6 (37–81)
    Sex
     Male13
     Female7
    Final diagnosis
     Pancreatic NET1
      Stage G17
      Stage G22
      Stage unclear6
     Duodenal NET2
     Rectal NET2
     Lymph node metastases of NET1
    • Qualitative data are numbers; continuous data are mean ± SD followed by range (n = 20 patients).

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Journal of Nuclear Medicine Technology: 48 (4)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 4
December 1, 2020
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Evaluation of a Correction Method for 111In-Pentetreotide SPECT Imaging of Gastroenteropancreatic Neuroendocrine Tumors
Takao Kanzaki, Yasuyuki Takahashi, Tetsuya Higuchi, Xieyi Zhang, Nao Mogi, Takayuki Suto, Yoshito Tsushima
Journal of Nuclear Medicine Technology Dec 2020, 48 (4) 326-330; DOI: 10.2967/jnmt.120.249680

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Evaluation of a Correction Method for 111In-Pentetreotide SPECT Imaging of Gastroenteropancreatic Neuroendocrine Tumors
Takao Kanzaki, Yasuyuki Takahashi, Tetsuya Higuchi, Xieyi Zhang, Nao Mogi, Takayuki Suto, Yoshito Tsushima
Journal of Nuclear Medicine Technology Dec 2020, 48 (4) 326-330; DOI: 10.2967/jnmt.120.249680
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Keywords

  • Somatostatin receptor scintigraphy
  • 111In-pentetreotide
  • NET
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