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Review ArticleTeaching Case Studies

Triple Tracer Positivity in Metastatic Lymph Nodes from Well-Differentiated Neuroendocrine Tumor in MEN-1 Syndrome

Anwin Joseph Kavanal, Sanjay K. Bhadada, Ashwani Sood, Gurjeet Kaur, Amber Parwaiz, Ajay Gulati, Divya Dahiya and Bhagwant Rai Mittal
Journal of Nuclear Medicine Technology September 2020, 48 (3) 287-289; DOI: https://doi.org/10.2967/jnmt.119.237339
Anwin Joseph Kavanal
1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Sanjay K. Bhadada
2Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Ashwani Sood
1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Gurjeet Kaur
2Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Amber Parwaiz
3Department of Cytopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Ajay Gulati
4Department of Radiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; and
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Divya Dahiya
5Department of General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Bhagwant Rai Mittal
1Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
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Abstract

Patients with multiple endocrine neoplasia type 1 usually have a combination of endocrine disorders due to lesions in the pancreas, parathyroid gland, and pituitary gland. Functional imaging using different tracers in addition to conventional imaging are applied in localizing the primary sites, determining the disease extent, and characterizing the lesions. We present a diagnosed case of multiple endocrine neoplasia type 1 with interesting incidental imaging findings showing 99mTc-sestamibi and 18F-fluorocholine uptake in addition to 68Ga-DOTANOC uptake in metastatic mediastinal and cervical lymph nodes arising from gastroenteropancreatic neuroendocrine tumor. This case shows the possibility of imaging the neuroendocrine tumors with 3 different tracers, namely 68Ga-DOTANOC, 99mTc-sestamibi, and 18F-fluorocholine.

  • neuroendocrine tumor
  • MEN-1
  • 18F-fluorocholine
  • 99mTc-sestamibi
  • 68Ga-DOTANOC

Footnotes

  • Published online Feb. 28, 2020.

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Journal of Nuclear Medicine Technology: 48 (3)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 3
September 1, 2020
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Triple Tracer Positivity in Metastatic Lymph Nodes from Well-Differentiated Neuroendocrine Tumor in MEN-1 Syndrome
Anwin Joseph Kavanal, Sanjay K. Bhadada, Ashwani Sood, Gurjeet Kaur, Amber Parwaiz, Ajay Gulati, Divya Dahiya, Bhagwant Rai Mittal
Journal of Nuclear Medicine Technology Sep 2020, 48 (3) 287-289; DOI: 10.2967/jnmt.119.237339

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Triple Tracer Positivity in Metastatic Lymph Nodes from Well-Differentiated Neuroendocrine Tumor in MEN-1 Syndrome
Anwin Joseph Kavanal, Sanjay K. Bhadada, Ashwani Sood, Gurjeet Kaur, Amber Parwaiz, Ajay Gulati, Divya Dahiya, Bhagwant Rai Mittal
Journal of Nuclear Medicine Technology Sep 2020, 48 (3) 287-289; DOI: 10.2967/jnmt.119.237339
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Keywords

  • Neuroendocrine tumor
  • MEN-1
  • 18F-fluorocholine
  • 99mTc-sestamibi
  • 68Ga-DOTANOC
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