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Research ArticleImaging

Accuracy of Dopamine Transporter Imaging with 123I-Ioflupane in Hispanic and Non-Hispanic Patients

Tamara F. Lundeen, Matthew Covington, Elizabeth A. Krupinski, Ryan Avery, Hong Lei, Scott J. Sherman and Phillip H. Kuo
Journal of Nuclear Medicine Technology June 2020, 48 (2) 154-157; DOI: https://doi.org/10.2967/jnmt.119.231423
Tamara F. Lundeen
1Department of Medical Imaging, University of Arizona/Banner University Medical Center, Tucson, Arizona
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Matthew Covington
2Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
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Elizabeth A. Krupinski
3Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia
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Ryan Avery
4Northwestern University, Chicago, Illinois
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Hong Lei
5Department of Neurology, University of Arizona/Banner University Medical Center, Tucson, Arizona; and
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Scott J. Sherman
5Department of Neurology, University of Arizona/Banner University Medical Center, Tucson, Arizona; and
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Phillip H. Kuo
1Department of Medical Imaging, University of Arizona/Banner University Medical Center, Tucson, Arizona
6Departments of Medicine and Biomedical Engineering, University of Arizona, Tucson, Arizona
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  • FIGURE 1.
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    FIGURE 1.

    Representative normal and abnormal 123I-ioflupane scan findings among study population ethnic groups: normal Hispanic (A), abnormal Hispanic (B), normal non-Hispanic (C), and abnormal non-Hispanic (D). Color version of this figure is available as a supplemental file at http://tech.snmjournals.org.

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    FIGURE 2.

    Schematic of rates of agreement between gold standard diagnosis and visual assessment of DaT imaging in Hispanic vs. non-Hispanic patients. dx = diagnostic.

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    TABLE 1

    Study Population Demographics

    DemographicTotal (n = 107)Hispanic (n = 30)Non-Hispanic (n = 77)
    Mean age (y)676468
    Age range (y)31–8831–8036–88
    Female (n)61 (57%)18 (60%)43 (56%)
    Male (n)46 (43%)12 (40%)34 (44%)
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    TABLE 2

    Rates of Agreement Between Gold Standard Clinical Diagnosis and Visual Assessment of DaT Imaging Between Hispanic and Non-Hispanic Patients

    CharacteristicSensitivitySpecificityPositive predictive valueNegative predictive value
    Hispanic100%92%94%100%
    Non-Hispanic92%88%94%85%
    Ethnicities combined94%90%94%90%
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Journal of Nuclear Medicine Technology: 48 (2)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 2
June 1, 2020
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Accuracy of Dopamine Transporter Imaging with 123I-Ioflupane in Hispanic and Non-Hispanic Patients
Tamara F. Lundeen, Matthew Covington, Elizabeth A. Krupinski, Ryan Avery, Hong Lei, Scott J. Sherman, Phillip H. Kuo
Journal of Nuclear Medicine Technology Jun 2020, 48 (2) 154-157; DOI: 10.2967/jnmt.119.231423

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Accuracy of Dopamine Transporter Imaging with 123I-Ioflupane in Hispanic and Non-Hispanic Patients
Tamara F. Lundeen, Matthew Covington, Elizabeth A. Krupinski, Ryan Avery, Hong Lei, Scott J. Sherman, Phillip H. Kuo
Journal of Nuclear Medicine Technology Jun 2020, 48 (2) 154-157; DOI: 10.2967/jnmt.119.231423
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Keywords

  • 123I-ioflupane
  • ethnic disparity
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