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Journal of Nuclear Medicine Technology

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Review ArticleContinuing Education

18F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities

Kriti Ahuja, Houman Sotoudeh, Samuel J. Galgano, Ramandeep Singh, Nishant Gupta, Siddhartha Gaddamanugu and Gagandeep Choudhary
Journal of Nuclear Medicine Technology March 2020, 48 (1) 9-16; DOI: https://doi.org/10.2967/jnmt.119.234336
Kriti Ahuja
1Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
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Houman Sotoudeh
1Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
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Samuel J. Galgano
1Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
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Ramandeep Singh
2Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts; and
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Nishant Gupta
3Department of Radiology, Columbia University at Bassett Healthcare, Cooperstown, New York
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Siddhartha Gaddamanugu
1Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
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Gagandeep Choudhary
1Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama
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Abstract

The skeleton is the third most common site for metastasis overall, after the lungs and liver. Accurate diagnosis of osseous metastasis is critical for initial staging, treatment planning, restaging, treatment monitoring, and survival prediction. Currently, 99mTc-methylene diphosphonate whole-body scanning is the cornerstone of imaging to detect osseous metastasis. Although 18F-sodium fluoride (18F-NaF) was one of the oldest medical tracers for this purpose, it was replaced by other tracers because of their better physical properties, until recently. Continued development of PET scanners has opened a new era for 18F-NaF, and given its higher sensitivity, there have been increasing applications in imaging. In this review, we will discuss the history, technical aspects, radiobiology, and biodistribution of this tracer. Finally, we compare the accuracy of 18F-NaF PET with other conventional imaging methods for detection of osseous metastasis.

  • 18F-sodium fluoride
  • PET/CT
  • bone scan
  • bone metastases
  • 99mTc-methylene diphosphonate

Footnotes

  • Published online Dec. 6, 2019.

  • CE credit: For CE credit, you can access the test for this article, as well as additional JNMT CE tests, online at https://www.snmmilearningcenter.org. Complete the test online no later than March 2023. Your online test will be scored immediately. You may make 3 attempts to pass the test and must answer 80% of the questions correctly to receive 1.0 CEH (Continuing Education Hour) credit. SNMMI members will have their CEH credit added to their VOICE transcript automatically; nonmembers will be able to print out a CE certificate upon successfully completing the test. The online test is free to SNMMI members; nonmembers must pay $15.00 by credit card when logging onto the website to take the test.

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Journal of Nuclear Medicine Technology: 48 (1)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 1
March 1, 2020
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18F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities
Kriti Ahuja, Houman Sotoudeh, Samuel J. Galgano, Ramandeep Singh, Nishant Gupta, Siddhartha Gaddamanugu, Gagandeep Choudhary
Journal of Nuclear Medicine Technology Mar 2020, 48 (1) 9-16; DOI: 10.2967/jnmt.119.234336

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18F-Sodium Fluoride PET: History, Technical Feasibility, Mechanism of Action, Normal Biodistribution, and Diagnostic Performance in Bone Metastasis Detection Compared with Other Imaging Modalities
Kriti Ahuja, Houman Sotoudeh, Samuel J. Galgano, Ramandeep Singh, Nishant Gupta, Siddhartha Gaddamanugu, Gagandeep Choudhary
Journal of Nuclear Medicine Technology Mar 2020, 48 (1) 9-16; DOI: 10.2967/jnmt.119.234336
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  • Article
    • Abstract
    • HISTORY
    • TECHNICAL ASPECTS
    • MECHANISM OF ACTION AND RADIOBIOLOGY
    • NORMAL BIODISTRIBUTION
    • COMPARISON
    • CONCLUSION
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Keywords

  • 18F-sodium fluoride
  • PET/CT
  • bone scan
  • bone metastases
  • 99mTc-methylene diphosphonate
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