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Journal of Nuclear Medicine Technology

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Research ArticleSpecial Contribution

Ambulatory Microdose PET: A Wearable PET Scanner for Neurologic Imaging

Rani M. Noble
Journal of Nuclear Medicine Technology December 2019, 47 (4) 336-340; DOI: https://doi.org/10.2967/jnmt.119.228718
Rani M. Noble
Nuclear Medicine Technology Program, Gateway Community College, Phoenix, Arizona
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  • FIGURE 1.
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    FIGURE 1.

    (Left) Original (generation 0) AM PET design. (Right) AM PET original bungee cord support frame. (Reprinted with permission of (6).)

  • FIGURE 2.
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    FIGURE 2.

    Generation 0 images. (Top left) A 2-mm-thick slice of brain after 1-min acquisition during head movement. A 333- to 444-MBq (9–12 mCi) dose of 18F-FDG was injected, and imaging took place after 2 half-lives had passed (74–111 MBq, or 2–3 mCi). Uptake is shown in frontal lobes and occipital cortex. Head of caudate can also be clearly identified. (Bottom left) Separate 2-mm slices were overlaid onto PET scan. This image was taken over 10 min. (Right) Concept of mobile imaging, using backpack to store electronics and support system for helmet. (Reprinted with permission of (6).)

  • FIGURE 3.
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    FIGURE 3.

    (A) Side view of 4-tiered 3-dimensionally printed helmet with virtual reality set. (B) Top view of 4-tiered helmet design. (C) Air bladder used for concept in 3-dimensionally printed helmet used to help give helmet tight and comfortable fit. (Reprinted with permission of (6).)

  • FIGURE 4.
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    FIGURE 4.

    Generation 1 support design, showing counterbalance that can support up to 10 kg but has ability to be changed. (Reprinted with permission of (6).)

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    TABLE 1

    Traditional PET Scanners Compared with Upright PET Scanners

    ScannerGeneral featureGeometryMotion-friendlySpatial resolutionSensitivity (%)Axial coverageSupport mechanics
    Whole-body PETStandard of careHorizontal, supine, or proneNo4–5 mm1Whole brainBed
    Helmet PETWearable feasibility prototypeUprightYes2–4 mm0.5∼5 cmPassive vertical weight support
    AM PET, generation 0Dissemination prototypeUprightYes2–5 mm3–5Whole brainPassive weight support
    AM PET, generation 1Dissemination prototypeUprightYes2–3 mm5–10Whole brainActive weight support
    • Reprinted with permission of (6).

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Journal of Nuclear Medicine Technology: 47 (4)
Journal of Nuclear Medicine Technology
Vol. 47, Issue 4
December 1, 2019
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Ambulatory Microdose PET: A Wearable PET Scanner for Neurologic Imaging
Rani M. Noble
Journal of Nuclear Medicine Technology Dec 2019, 47 (4) 336-340; DOI: 10.2967/jnmt.119.228718

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Ambulatory Microdose PET: A Wearable PET Scanner for Neurologic Imaging
Rani M. Noble
Journal of Nuclear Medicine Technology Dec 2019, 47 (4) 336-340; DOI: 10.2967/jnmt.119.228718
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  • Article
    • Abstract
    • THE ORIGIN OF THE WEARABLE PET SCANNER
    • WEARABLE PET SCANNER TECHNOLOGY FOR HUMANS
    • UNWEIGHTING SYSTEM
    • UNWEIGHTING SYSTEM TESTING RESULTS
    • NEUROLOGIC IMAGING POSITIONING SYSTEMS
    • RADIOTRACERS
    • EARLY STUDY RESULTS
    • OBSTACLES
    • CONCLUSION
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Keywords

  • brain
  • wearable
  • positron emission tomography
  • microdose
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