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Review ArticleContinuing Education

An Introduction to Newer PET Diagnostic Agents and Related Therapeutic Radiopharmaceuticals

Ellie Mantel and Jessica Williams
Journal of Nuclear Medicine Technology September 2019, 47 (3) 203-209; DOI: https://doi.org/10.2967/jnmt.118.224022
Ellie Mantel
1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania; and
CNMT, RT(N), FSNMMITS
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Jessica Williams
2Molecular Imaging Department, Harley Street Clinic, HCA Healthcare, London, England
CNMT, RT(N), FSNMMITS
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Figures

  • FIGURE 1.
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    FIGURE 1.

    Two images from same patient obtained 3 wk apart: planar 111In-octreotide scan (A) and 68Ga-DOTATATE PET scan (B). Lesions within liver are more easily identified on higher resolution of PET scan than on planar octreotide scan.

  • FIGURE 2.
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    FIGURE 2.

    Abnormal uptake (arrows) of 18F-fluciclovine in metastatic lymph node in right pelvis on PET images obtained 5–16 min after injection (A), 17–28 min after injection (B), and 29–40 min after injection (C). Uptake increases in urinary bladder over time.

  • FIGURE 3.
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    FIGURE 3.

    Abnormal uptake of 11C-choline in right ilium and pubis on PET (left panels in A and B) and PET/CT (right panels in A and B) images obtained before (A) and after (B) treatment.

  • FIGURE 4.
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    FIGURE 4.

    18F-FDG (A) and 11C-acetate (B) uptake (arrows) on PET images of patient with metastatic prostate cancer.

  • FIGURE 5.
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    FIGURE 5.

    18F-fluciclovine (A) and 68Ga-PSMA (B) uptake on PET images of patient with metastatic prostate cancer. Faint uptake of 18F-fluciclovine is seen in left prostate gland (blue arrow), and uptake of 68Ga-PSMA is seen in prostate gland and extrapelvic lymph nodes (yellow arrows).

  • FIGURE 6.
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    FIGURE 6.

    Transaxial PET slices demonstrating 18F-florbetapir–negative scan (left) and amyloid-positive scan (right).

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    FIGURE 7.

    Transaxial PET slices demonstrating 18F-flutametamol–negative scan (left) and amyloid-positive scan (right).

  • FIGURE 8.
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    FIGURE 8.

    Sagittal and transaxial PET slices demonstrating 18F-florbetaben–negative scan (left) and 18F-florbetaben–positive scan (right). SUVR = SUV ratio.

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    FIGURE 9.

    Short-axis (top), vertical long-axis (middle), and horizontal long-axis (bottom) PET myocardial perfusion images obtained using 18F-flurpiridaz during various cardiac and respiratory gating. Cardiac MF = cardiac motion frozen, no respiratory gating; ORG = optimal respiratory gating.

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Journal of Nuclear Medicine Technology: 47 (3)
Journal of Nuclear Medicine Technology
Vol. 47, Issue 3
September 1, 2019
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An Introduction to Newer PET Diagnostic Agents and Related Therapeutic Radiopharmaceuticals
Ellie Mantel, Jessica Williams
Journal of Nuclear Medicine Technology Sep 2019, 47 (3) 203-209; DOI: 10.2967/jnmt.118.224022
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  • Article
    • Abstract
    • RADIOPHARMACEUTICALS FOR NETS
    • RADIOPHARMACEUTICALS FOR PROSTATE CANCER
    • RADIOPHARMACEUTICALS FOR NEUROLOGIC PET IMAGING
    • RADIOPHARMACEUTICALS FOR MYOCARDIAL PERFUSION IMAGING
    • CONCLUSION
    • DISCLOSURE
    • Footnotes
    • REFERENCES
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Keywords

  • neuroendocrine tumor
  • prostate cancer
  • Alzheimer disease
  • amyloid imaging
  • cardiovascular imaging
  • neurologic PET imaging
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An Introduction to Newer PET Diagnostic Agents and Related Therapeutic Radiopharmaceuticals
Ellie Mantel, Jessica Williams
Journal of Nuclear Medicine Technology Sep 2019, 47 (3) 203-209; DOI: 10.2967/jnmt.118.224022

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