Research ArticleImaging

Regional Changes in Brain 18F-FDG Uptake After Prophylactic Cranial Irradiation and Chemotherapy in Small Cell Lung Cancer May Reflect Functional Changes

Naghmehossadat Eshghi, Linda L. Garland, Gagandeep Choudhary, Charles C. Hsu, Anna Eshghi, James Han, Russell J. Hamilton, Elizabeth Krupinski and Phillip H. Kuo
Journal of Nuclear Medicine Technology December 2018, 46 (4) 355-358; DOI: https://doi.org/10.2967/jnmt.118.212316

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    Subtracted pre- and post-PCI 18F-FDG PET images using MIMneuro software are presented in transaxial (left), sagittal (middle), and coronal (right) planes. A region of right frontal lobe (white arrows) was calculated to have 18F-FDG uptake difference greater than z score ≥ +2.5. A region of left occipital lobe (black arrow) also demonstrated difference after subtraction.

Tables

  • TABLE 1

    Patient Characteristics (n = 13)

    CharacteristicData
    Age (y)
     Mean65
     Range49–78
    Sex
     Female6 (46%)
     Male7 (54%)
    Stage of disease
     Limited5 (38%)
     Extensive8 (62%)
  • TABLE 2

    Regional z Score Differences for Each Patient (n = 13)

    Cerebral regions affectedRegionz score
    One, unilaterally
     1R frontal+
     2R frontal+
     3R frontal−
     4L frontal+
     5R frontal−
     6L temporal+
     7L temporal+
     8R parietal+
     9R parietal−
    Two, unilaterally
     10L parietal−
     R frontal+
     11L frontal+
     L parietal−
     12R parietal+
     L temporal+
    One, bilaterally
     13R frontal+
     L frontal+

    • + = z ≥ 2.5; − = z ≤ −2.5.

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