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Review ArticleTeaching Case Studies

Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE in Carcinoid Heart Disease: A Contraindication or a Promising Treatment Approach Bettering Chances for Corrective Surgery?

Sudha Ramesh, Shreyas Kudachi and Sandip Basu
Journal of Nuclear Medicine Technology September 2018, 46 (3) 292-294; DOI: https://doi.org/10.2967/jnmt.118.210179
Sudha Ramesh
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, India; and Homi Bhabha National Institute, Mumbai, India
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Shreyas Kudachi
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, India; and Homi Bhabha National Institute, Mumbai, India
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Sandip Basu
Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, India; and Homi Bhabha National Institute, Mumbai, India
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  • FIGURE 1.
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    FIGURE 1.

    68Ga-DOTATATE PET/CT axial slices showing partial response of hepatic lesions.

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    FIGURE 2.

    68Ga-DOTATATE PET/CT maximum-intensity projection (MIP) showing partial response of hepatic lesions.

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    TABLE 1

    24-Hour Urinary 5-HIAA After PRRT

    PRRT cycles5-HIAA (mg/24 h)
    At baseline243
    After 3 cycles96
    After 6 cycles41
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    TABLE 2

    2D Echocardiography Findings

    ParameterBefore therapyAfter 6 cycles
    Right ventricular ejection fraction (%)4550
    Right ventricle size (cm)4.14.3
    Right atrium size (cm)5.86.0
    Tricuspid regurgitationSevereSevere
    Tricuspid stenosisSevereModerate
    Pulmonary stenosisModerateMild
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Journal of Nuclear Medicine Technology: 46 (3)
Journal of Nuclear Medicine Technology
Vol. 46, Issue 3
September 1, 2018
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Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE in Carcinoid Heart Disease: A Contraindication or a Promising Treatment Approach Bettering Chances for Corrective Surgery?
Sudha Ramesh, Shreyas Kudachi, Sandip Basu
Journal of Nuclear Medicine Technology Sep 2018, 46 (3) 292-294; DOI: 10.2967/jnmt.118.210179
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Keywords

  • 177Lu-DOTATATE PRRT
  • Carcinoid Heart Disease
  • neuroendocrine tumor
  • long-acting octreotide
  • 5-hydroxyindole acetic acid (5-HIAA)
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Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE in Carcinoid Heart Disease: A Contraindication or a Promising Treatment Approach Bettering Chances for Corrective Surgery?
Sudha Ramesh, Shreyas Kudachi, Sandip Basu
Journal of Nuclear Medicine Technology Sep 2018, 46 (3) 292-294; DOI: 10.2967/jnmt.118.210179

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