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Research ArticleImaging

Technical Advances in Image Guidance of Radionuclide Therapy

Casper Beijst, Britt Kunnen, Marnix G.E.H. Lam and Hugo W.A.M. de Jong
Journal of Nuclear Medicine Technology December 2017, 45 (4) 272-279; DOI: https://doi.org/10.2967/jnmt.117.190991
Casper Beijst
1Department of Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, The Netherlands; and
2Image Sciences Institute, UMC Utrecht, Utrecht, The Netherlands
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Britt Kunnen
1Department of Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, The Netherlands; and
2Image Sciences Institute, UMC Utrecht, Utrecht, The Netherlands
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Marnix G.E.H. Lam
1Department of Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, The Netherlands; and
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Hugo W.A.M. de Jong
1Department of Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, The Netherlands; and
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Figures

  • FIGURE 1.
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    FIGURE 1.

    Face (A) and back (B) of parallel-cone (PC) collimator. (C) Double-point-source Monte Carlo simulations obtained for 131I on PC collimator and high-energy general-purpose (HEGP) collimator. PC collimator can detect the 2 sources separately, whereas HEGP collimator cannot. (Reprinted from (8).)

  • FIGURE 2.
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    FIGURE 2.

    Interventional pinhole SPECT camera mounted on 6-axis arm robot (58). The images show how the robotic gantry is able to acquire tomographic images from multiple angles.

  • FIGURE 3.
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    FIGURE 3.

    Explorer total-body PET scanner. (Courtesy of Drs. Simon R. Cherry and Ramsey D. Badawi, University of California, Davis.)

  • FIGURE 4.
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    FIGURE 4.

    Decay scheme of several isotopes that emit prompt γ-rays in cascade with positron emission (59).

  • FIGURE 5.
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    FIGURE 5.

    (A) Hybrid C-arm showing field of view of pinhole collimator and x-ray photons. (B) Entire system (50).

  • FIGURE 6.
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    FIGURE 6.

    Diagnostic 123I-MIBG planar acquisitions at 4 h (A) and 24 h (D) after injection, posttherapy 131I-MIBG planar acquisitions at 24 h (B) and 48 h (E) after injection, and 124I-MIBG maximum-intensity-projection acquisitions at 24 h (C) and 48 h (F) after injection (51). Resolution advantage of 124I PET over 123I and 131I SPECT is clear.

  • FIGURE 7.
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    FIGURE 7.

    Comparison of dose estimates based on 90Y PET and 90Y SPECT images after radioembolization procedure. (A) Graph shows cumulative dose–volume histogram of whole liver (WL), low-dose region of interest (LD), and high-dose region of interest (HD). (B and C) Same transversal slice through SPECT-based dose map fused with CT (B) and through PET-based dose map (C) (60) shows advantage of PET over SPECT in terms of resolution and effect on calculated dose distribution.

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Journal of Nuclear Medicine Technology: 45 (4)
Journal of Nuclear Medicine Technology
Vol. 45, Issue 4
December 1, 2017
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Technical Advances in Image Guidance of Radionuclide Therapy
Casper Beijst, Britt Kunnen, Marnix G.E.H. Lam, Hugo W.A.M. de Jong
Journal of Nuclear Medicine Technology Dec 2017, 45 (4) 272-279; DOI: 10.2967/jnmt.117.190991

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Technical Advances in Image Guidance of Radionuclide Therapy
Casper Beijst, Britt Kunnen, Marnix G.E.H. Lam, Hugo W.A.M. de Jong
Journal of Nuclear Medicine Technology Dec 2017, 45 (4) 272-279; DOI: 10.2967/jnmt.117.190991
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  • Article
    • Abstract
    • SPECT AND SCINTIGRAPHY
    • PET
    • OTHER MODALITIES FOR GUIDANCE
    • FUTURE PERSPECTIVES
    • CONCLUSION
    • DISCLOSURE
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Keywords

  • imaging
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