Comparison of 3 Devices for Automated Infusion of Positron-Emitting Radiotracers

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FIGURE 1.
Manufactured automated infusion devices evaluated in this study: M-130 (A), AI-300 (B), and UG-05 (C).
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FIGURE 2.
Scheme of measurement and administration process of each device: M-130 (A), AI-300 (B), and UG-05 (C).
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FIGURE 3.
Variations in radioactive concentrations (A) and dispensed volumes (B). ○ = AI-300; ● = M-130; × = UG-05.
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FIGURE 4.
Administration accuracy of AI-300 before and after software update. ○ = original; ● = update.

TABLE 1

Main Technical Features of Automated Infusion Devices

	Automated infusion device
Feature	M-130	AI-300	UG-05
Maximum radioactivity of multidose vial (MBq)	18,500	37,000	37,000
Maximum radioactive concentration of multidose vial (MBq/mL)	1,500	1,500	1,200
Range of net administration (MBq)	100–740	50–740	−740
Measurement accuracy of radioactive concentration (%)	±10	±5	±5
Measurement accuracy of radioactivity (%)	±10	±5	±5
Administration accuracy (%)	±10	±5	±5
Variation of volume	Constancy	Variability	Constancy
Measurement sample	Tube	Syringe	Vial

TABLE 2

Comparison of Accuracy of Administered ¹⁸F-FDG Radioactivity Between Automated Infusion Device and External Dose Calibrator

Devices	Sample	Radioactive concentration (MBq/mL)	Dispensed volume of ¹⁸F-FDG (mL)	Radioactivity recorded by device (MBq)	External measurement (MBq)	Administration accuracy (%)	Radioactive concentration (MBq/mL)	Dispensed volume of ¹⁸F-FDG (mL)	Radioactivity recorded by devise (MBq)	External measurement (MBq)	Administration accuracy (%)
M-130	1	294.12	0.17	48.42	50.33	−3.79	225.94	0.84	189.79	192.89	−1.60
	2	121.95	0.41	48.40	49.76	−2.72	127.32	1.40	178.25	179.58	−0.74
	3	200.00	0.25	49.26	50.05	−1.59	202.31	0.87	176.01	178.43	−1.36
	4	147.06	0.34	48.52	49.84	−2.66	152.30	1.17	178.20	180.36	−1.20
	5	166.67	0.30	48.19	49.97	−3.56	167.53	1.04	174.23	172.64	0.92
	6	142.86	0.35	24.07	24.42	−1.42	59.61	1.54	91.80	94.27	−2.63
AI-300	1	104.17	0.48	48.87	47.87	2.09	118.80	1.42	168.70	169.63	−0.55
	2	131.58	0.38	50.09	49.34	1.52	165.57	1.12	185.44	170.62	8.68
	3	147.06	0.34	50.61	44.54	13.64	178.59	1.04	185.73	175.66	5.73
	4	131.58	0.38	52.01	46.88	10.94	161.71	1.14	184.35	173.83	6.05
	5	151.52	0.33	49.01	42.83	14.42	177.28	1.05	186.14	171.39	8.61
	6	161.29	0.31	48.93	47.98	1.99	183.62	1.01	185.46	182.75	1.48
UG-05	1	90.79	0.60	54.48	51.27	6.26	92.04	2.01	180.23	174.92	3.04
	2	154.73	0.34	52.61	50.16	4.87	181.37	1.02	147.90	141.92	4.21
	3	205.09	0.26	53.32	52.14	2.27	205.56	0.90	185.01	175.61	5.35
	4	206.85	0.26	53.78	50.56	6.37	179.61	1.03	179.35	177.29	1.16
	5	224.45	0.25	56.11	52.98	5.92	212.64	0.87	182.29	173.10	5.31
	6	108.58	0.39	42.34	42.40	−0.13	411.11	0.45	191.05	187.63	1.83