TY - JOUR T1 - Comparison of 3 Devices for Automated Infusion of Positron-Emitting Radiotracers JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 91 LP - 95 DO - 10.2967/jnmt.116.188243 VL - 45 IS - 2 AU - Noriaki Miyaji AU - Kenta Miwa AU - Kei Wagatsuma AU - Taisuke Murata AU - Takuro Umeda AU - Takashi Terauchi AU - Mitsuru Koizumi Y1 - 2017/06/01 UR - http://tech.snmjournals.org/content/45/2/91.abstract N2 - The administration accuracy and precision of an automated infusion device for positron-emitting radiotracers are directly associated with bias and variance in the SUVs of 18F-FDG PET/CT. Therefore, the accuracy of such devices must be confirmed and calibrated at locations in which they are used. The present study aimed to validate the administration accuracy of 3 automated infusion devices for quantitative PET assessment. Methods: Temporal variations as well as variations in radioactive concentrations and dispensed volumes of 18F-FDG were determined for the M-130, AI-300, and UG-05 automated infusion devices. The total-test dispensed volumes were 25, 20, and 18.5 mL, respectively. A reference value was generated by measuring amounts of radioactivity using a standard dose calibrator. Administration accuracy was validated according to the criteria of the Japanese Society of Nuclear Medicine. Results: The temporal variation in the M-130 and UG-05 for a specified 185 MBq was relatively stable, in the range of −1.60%–0.92% and 1.16%–5.35%, respectively, whereas that in the AI-300 was −0.55%–8.68%. For the M-130 and UG-05 devices, the difference between measured and reference value was in the range of −5%–5%. The values measured by the AI-300 deviated from the reference values by a maximum of 30%, which depends on radioactive concentration and dispensed volume of 18F-FDG. Conclusion: The administration accuracy of the AI-300 varied considerably under different conditions, but a software update might somewhat improve this. Our findings indicate that dispensed volumes of 18F-FDG should be carefully considered when the radioactive concentration is high. Administration accuracy should be regularly confirmed at each location to maintain the quality of quantitative PET assessment. The present study provides useful information about how to confirm the administration accuracy of automated infusion devices. ER -