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Research ArticleImaging

Metabolic Signature on 18F-FDG PET/CT, HER2 Status, and Survival in Gastric Adenocarcinomas

Romulo Celli, Monica Colunga, Natalie Patel, Mehdi Djekidel and Dhanpat Jain
Journal of Nuclear Medicine Technology December 2016, 44 (4) 234-238; DOI: https://doi.org/10.2967/jnmt.116.181479
Romulo Celli
1Department of Pathology, Yale School of Medicine, New Haven, Connecticut
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Monica Colunga
2Sciences Po, Paris, France; and
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Natalie Patel
1Department of Pathology, Yale School of Medicine, New Haven, Connecticut
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Mehdi Djekidel
3QMC Quality Medical Consulting, Hamden, Connecticut
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Dhanpat Jain
1Department of Pathology, Yale School of Medicine, New Haven, Connecticut
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    FIGURE 1.

    SUVmax, by HER2 status.

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    FIGURE 2.

    Overall survival, by HER2 status.

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    FIGURE 3.

    Overall survival, by SUVmax (above and below median SUVmax of 6.6).

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    FIGURE 4.

    Overall survival, by tumor differentiation.

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    TABLE 1

    Clinical Characteristics

    HER2+ (n = 31)HER2− (n = 65)P
    Age (y)70 (±12.6)67 (±12.5)0.23
    Sex0.61
     Male24 (77%)45 (69%)
     Female7 (23%)20 (31%)
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    TABLE 2

    Tumor Pathologic Characteristics

    Pathologic characteristicHER2+HER2−P
    Histologyn = 26n = 61
     Intestinal21 (81%)31 (57%)0.11
     Diffuse5 (24%)19 (36%)
     Medullary04 (8%)
    Differentiationn = 30n = 61
     Well01 (2%)
     Moderately16 (53%)17 (27%)
     Poorly14 (47%)43 (68%)0.06
    Lymph node metastasesn = 10n = 30
     Yes6 (60%)12 (40%)0.26
     No4 (40%)18 (60%)
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Journal of Nuclear Medicine Technology: 44 (4)
Journal of Nuclear Medicine Technology
Vol. 44, Issue 4
December 1, 2016
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Metabolic Signature on 18F-FDG PET/CT, HER2 Status, and Survival in Gastric Adenocarcinomas
Romulo Celli, Monica Colunga, Natalie Patel, Mehdi Djekidel, Dhanpat Jain
Journal of Nuclear Medicine Technology Dec 2016, 44 (4) 234-238; DOI: 10.2967/jnmt.116.181479

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Metabolic Signature on 18F-FDG PET/CT, HER2 Status, and Survival in Gastric Adenocarcinomas
Romulo Celli, Monica Colunga, Natalie Patel, Mehdi Djekidel, Dhanpat Jain
Journal of Nuclear Medicine Technology Dec 2016, 44 (4) 234-238; DOI: 10.2967/jnmt.116.181479
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Keywords

  • Metabolic signature
  • Gastric carcinoma
  • HER2
  • 18F-FDG PET/CT
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