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Research ArticleImaging

Determining the Minimal Required Radioactivity of 18F-FDG for Reliable Semiquantification in PET/CT Imaging: A Phantom Study

Ming-Kai Chen, David H. Menard and David W. Cheng
Journal of Nuclear Medicine Technology March 2016, 44 (1) 26-30; DOI: https://doi.org/10.2967/jnmt.115.165258
Ming-Kai Chen
1Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut
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David H. Menard III
2Yale–New Haven Hospital, New Haven, Connecticut; and
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David W. Cheng
3Sidra Medical and Research Center, Doha, Qatar
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  • FIGURE 1.
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    FIGURE 1.

    (A) Standard Jaszczak ECT phantom with solid spheres replaced by hollow spheres. (B) Hollow spheres with diameters of 3.4, 2.1, 1.5, 1.2, 1.0, and 0.5 cm. (C) Image of spheres filled with 18F-FDG (165 kBq/mL). (D) Transaxial reconstructed images at 0, 4, 6, 8, 10, 12, 13.5, 14.5, 15.5, 16.5, 17.5, and 18.5 h of decay (displayed in 3-min reconstruction).

  • FIGURE 2.
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    FIGURE 2.

    Impact of radioactivity concentration on SUVmax (A) and SUVavg (B) in spheres of various sizes using 10-min acquisition. Radioactivity concentrations on x-axis correspond to acquisition time points of approximately 0, 4, 6, 8, 10, 12, 13.5, 14.5, 15.5, 16.5, 17.5, and 18.5 h.

  • FIGURE 3.
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    FIGURE 3.

    Impact of total radioactivity on SUVmax (A) and SUVavg (B) in 3.4-cm sphere at various acquisition times. SUVmax is significantly overestimated at earlier acquisitions (47 at 1-min acquisition compared with 9–10 at later acquisitions). Likewise, SUVavg is overestimated at earlier acquisitions (33.6 at 1-min acquisition compared with 7–8 at later acquisitions). Counting rates are not corrected for random counts or dead time.

  • FIGURE 4.
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    FIGURE 4.

    Use of radioactivity concentration–acquisition time product to determine reproducibility of SUVmax in spheres of various sizes. SUVmax is overestimated within a low range of concentration–time product. Data for typical (A) and expanded (B and C) x-axes are shown.

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Journal of Nuclear Medicine Technology: 44 (1)
Journal of Nuclear Medicine Technology
Vol. 44, Issue 1
March 1, 2016
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Determining the Minimal Required Radioactivity of 18F-FDG for Reliable Semiquantification in PET/CT Imaging: A Phantom Study
Ming-Kai Chen, David H. Menard, David W. Cheng
Journal of Nuclear Medicine Technology Mar 2016, 44 (1) 26-30; DOI: 10.2967/jnmt.115.165258

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Determining the Minimal Required Radioactivity of 18F-FDG for Reliable Semiquantification in PET/CT Imaging: A Phantom Study
Ming-Kai Chen, David H. Menard, David W. Cheng
Journal of Nuclear Medicine Technology Mar 2016, 44 (1) 26-30; DOI: 10.2967/jnmt.115.165258
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