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Research ArticleImaging

Reproducibility Between Brain Uptake Ratio Using Anatomic Standardization and Patlak-Plot Methods

Takayuki Shibutani, Masahisa Onoguchi, Atsushi Noguchi, Tomoki Yamada, Hiroko Tsuchihashi, Tadashi Nakajima and Seigo Kinuya
Journal of Nuclear Medicine Technology December 2015, 43 (4) 261-266; DOI: https://doi.org/10.2967/jnmt.115.162115
Takayuki Shibutani
1Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan
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Masahisa Onoguchi
1Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan
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Atsushi Noguchi
2Department of Radiological Technology, Faculty of Health Sciences, Butsuryo College of Osaka, Osaka, Japan
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Tomoki Yamada
3Department of Radiological Technology, Kishiwada City Hospital, Osaka, Japan; and
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Hiroko Tsuchihashi
3Department of Radiological Technology, Kishiwada City Hospital, Osaka, Japan; and
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Tadashi Nakajima
3Department of Radiological Technology, Kishiwada City Hospital, Osaka, Japan; and
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Seigo Kinuya
4Department of Biotracer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
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  • FIGURE 1.
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    FIGURE 1.

    The 12 ROIs standardized using 3DSRT: callosomarginal, precentral, central, parietal, angular, temporal, posterior cerebral, pericallosal, lenticular nuclear, thalamic, hippocampal, and cerebellar.

  • FIGURE 2.
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    FIGURE 2.

    Flowchart for Patlak-plot, BUR-C, and BUR-AS methods. Patlak and BUR-C include manual processing. BUR-AS includes manual processing for aortic ROI and time–activity curve range and automatic processing for basal ganglia ROI and slice selection. mCBF and mSPECT = mean CBF and SPECT counts, respectively; TAC = time–activity curve.

  • FIGURE 3.
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    FIGURE 3.

    CVs for interoperator reproducibility. CV is significantly lowest for BUR-AS.

  • FIGURE 4.
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    FIGURE 4.

    Bland–Altman plots for interoperator reproducibility. Difference is lowest for BUR-AS.

  • FIGURE 5.
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    FIGURE 5.

    Examples of ROI setting and γ fitting by the 3 radiologic technologists (RT1, RT2, and RT3). At top are the dynamic image slices and the chosen ROI; at bottom are graphs of time–activity curves.

  • FIGURE 6.
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    FIGURE 6.

    CVs for intraoperator reproducibility for the 3 radiologic technologists (RT1, RT2, and RT3). CV was lowest for BUR-AS; CV for BUR-C for RT2 and Patlak plot for RT3 did not significantly differ.

  • FIGURE 7.
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    FIGURE 7.

    Bland–Altman plots for intraoperator reproducibility. Difference is lowest for BUR-AS.

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Journal of Nuclear Medicine Technology: 43 (4)
Journal of Nuclear Medicine Technology
Vol. 43, Issue 4
December 1, 2015
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Reproducibility Between Brain Uptake Ratio Using Anatomic Standardization and Patlak-Plot Methods
Takayuki Shibutani, Masahisa Onoguchi, Atsushi Noguchi, Tomoki Yamada, Hiroko Tsuchihashi, Tadashi Nakajima, Seigo Kinuya
Journal of Nuclear Medicine Technology Dec 2015, 43 (4) 261-266; DOI: 10.2967/jnmt.115.162115

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Reproducibility Between Brain Uptake Ratio Using Anatomic Standardization and Patlak-Plot Methods
Takayuki Shibutani, Masahisa Onoguchi, Atsushi Noguchi, Tomoki Yamada, Hiroko Tsuchihashi, Tadashi Nakajima, Seigo Kinuya
Journal of Nuclear Medicine Technology Dec 2015, 43 (4) 261-266; DOI: 10.2967/jnmt.115.162115
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Keywords

  • Brain perfusion SPECT
  • patlak plot method
  • brain uptake ratio
  • reproducibility
  • cerebral blood flow (CBF)
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