Radiotracer Imaging of Peripheral Vascular Disease

Multimodality evaluation with ankle–brachial indices (A), CT angiography (B), and hybrid ^99mTc-tetrofosmin SPECT/CT (C) reveals impaired lower-extremity pressures and tissue perfusion in PVD patient with previously implanted aortoiliac stents (B). Segmentation of muscle groups into 3-dimensional regions of interest by CT attenuation images (D) confirmed differences in regional tissue perfusion between legs (E). Red = gastrocnemius; yellow = soleus; green = tibialis; purple = fibularis; ABI = ankle–brachial index; PPG = photoplethysmograph; PVR = pulse volume recording; TBI = toe–brachial index.

Lower-extremity PET H₂¹⁵O imaging of healthy subject and PVD patient during selective adenosine infusion into left leg (A). Baseline and adenosine stress blood flow was assessed, and flow reserve was expressed as ratio of adenosine flow to baseline flow (B). Flow reserve was significantly lower in PVD patients than in healthy subjects. (Reprinted from (32).).

PET/CT imaging with ⁶⁴Cu-DOTA–C-type atrial natriuretic factor–comb (A) and ⁶⁴Cu-DOTA–comb (B) in mouse model of hind limb ischemia, 7 d after femoral artery occlusion. ⁶⁴Cu-DOTA–C-type atrial natriuretic factor–comb uptake was significantly higher than uptake of ⁶⁴Cu-DOTA–comb in ischemic limb when percentage injected tracer dose per gram of tissue (C) or ischemic-to-nonischemic leg ratios (D) were examined. (Reprinted from (52).) CANF = C-type atrial natriuretic factor.