RT Journal Article
SR Electronic
T1 Radiotracer Imaging of Peripheral Vascular Disease
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 185
OP 192
DO 10.2967/jnumed.112.115105
VO 43
IS 3
A1 Mitchel R. Stacy
A1 Wunan Zhou
A1 Albert J. Sinusas
YR 2015
UL http://tech.snmjournals.org/content/43/3/185.abstract
AB Peripheral vascular disease (PVD) is an atherosclerotic disease affecting the lower extremities, resulting in skeletal muscle ischemia, intermittent claudication, and, in more severe stages of disease, limb amputation and death. The evaluation of therapy in this patient population can be challenging, as the standard clinical indices are insensitive to assessment of regional alterations in skeletal muscle physiology. Radiotracer imaging of the lower extremities with techniques such as PET and SPECT can provide a noninvasive quantitative technique for the evaluation of the pathophysiology associated with PVD and may complement clinical indices and other imaging approaches. This review discusses the progress in radiotracer-based evaluation of PVD and highlights recent advancements in molecular imaging with potential for clinical application.