Article Figures & Data
Figures
- FIGURE 1.
RCP values of 99mTc-FSC over 6 h. Solid line represents 5-min heating. Dashed line represents 3-min heating. Dotted line represents RCP acceptance level as per United States Pharmacopeia (92%).
- FIGURE 2.
Electron micrographs of 99mTc-FSC particles at ×59,000 magnification. (Left) 99mTc-FSC particles with 5-min heating at 0 h. (Right) 99mTc-FSC particles with 3-min heating at 0 h.
- FIGURE 3.
Relative frequency of particle size for samples with 3-min heating. Along x-axis are particle sizes (nm), and y-axis represents relative frequency (%) that particle sizes (within small range) occur in sample. Solid lines represent 0-h readings, and dashed lines represent 6-h readings. Vertical lines indicate median particle size for sample.
- FIGURE 4.
Relative frequency of particle size for samples with 5-min heating. Along x-axis are particle sizes (nm), and y-axis represents relative frequency (%) that particle sizes (within small range) occur in sample. Solid lines represent 0-h readings, and dashed lines represent 6-h readings. Vertical lines indicate median particle size for sample.
Tables
- TABLE 1
Retained 0.22-μm Filtered Activity of 99mTc-SC Prepared with 3- or 5-Minute Heating at 0 Hours
Trial 3-min heating (%) 5-min heating (%) 1 39.7 36.4 2 28.7 34.7 3 34.5 30.2 4 34.8 40.5 5 31.5 34.3 6 33.2 32.1 Average ± SD 33.7 ± 3.7 34.7 ± 3.6 3-min heating (nm) 5-min heating (nm) 0 h 6 h 0 h 6 h 24 (20, 34) 34 (28, 41) 28 (18, 56) 22 (17, 26) 29 (21, 40) 40 (29, 50) 23 (17, 32) 29 (24, 35) 22 (16, 30) 33 (26, 41) 34 (25, 50) 38 (26, 61) 24 (19, 34) 35 (28, 44) 29 (20, 43) 27 (21, 39) Data are median (25th percentile, 75th percentile). Final row is average of top 3 rows of data from sample runs.
Size (nm) 3-min heating (%) 5-min heating (%) 0 h 6 h 0 h 6 h 0–14 8.8 2.2 10.2 6.34 15–30 58.7 33.1 42.6 51.8 31–100 32.3 64.4 46.2 39.5 101–220 13.8 0.3 1.0 2.3 >220 0 0 0 0
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