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Research ArticleIMAGING

Antiepileptic Treatment Is Associated with Bone Loss: Difference in Drug Type and Region of Interest

Hooman Salimipour, Sara Kazerooni, Mohammad Seyedabadi, Iraj Nabipour, Reza Nemati, Darioush Iranpour and Majid Assadi
Journal of Nuclear Medicine Technology September 2013, 41 (3) 208-211; DOI: https://doi.org/10.2967/jnmt.113.124685
Hooman Salimipour
1Department of Neurology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
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Sara Kazerooni
2Department of Pediatrics, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
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Mohammad Seyedabadi
3Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran; and
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Iraj Nabipour
4Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
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Reza Nemati
1Department of Neurology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
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Darioush Iranpour
3Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran; and
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Majid Assadi
3Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran; and
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  • Article
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Article Figures & Data

Tables

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    TABLE 1

    The Effects of Drug Type on BMD

    RegionGroupnMeanSD95% CI
    Lumbar spineControl381.0290.1310.986–1.072
    EIAEDs720.906*0.2030.858–0.954
    Non-EIAEDs360.905*0.2150.832–0.977
    Ward triangleControl380.8730.2540.79–0.957
    EIAEDs720.7760.3440.695–0.856
    Non-EIAEDs360.7720.3750.645–0.899
    Greater trochanterControl380.7290.1190.690–0.769
    EIAEDs720.6820.1340.651–0.714
    Non-EIAEDs360.7220.1430.674–0.771
    Femoral neckControl381.0040.1020.971–1.038
    EIAEDs720.922*0.1610.884–0.96
    Non-EIAEDs360.9460.1640.890–1.001
    Total hipControl380.8690.1410.822–0.915
    EIAEDs720.7930.1840.75–0.837
    Non-EIAEDs360.8130.2030.745–0.882
    • ↵* P < 0.05, compared with control.

    • CI = confidence interval.

    • View popup
    TABLE 2

    The Effects of Monotherapy or Polytherapy on BMD

    RegionTherapynMeanSD95% CI
    Lumbar spinePolytherapy520.9330.1880.881–0.985
    Carbamazepine monotherapy330.848*0.2130.772–0.924
    Valproate monotherapy220.9170.2310.814–1.019
    Control381.02890.1310.986–1.072
    Ward trianglePolytherapy520.7920.3070.706–0.877
    Carbamazepine monotherapy330.7440.3940.604–0.884
    Valproate monotherapy220.7810.4070.601–0.962
    Control380.8730.2540.79–0.957
    Greater trochanterPolytherapy520.7080.1400.669–0.747
    Carbamazepine monotherapy330.6560.1340.608–0.703
    Valproate monotherapy220.7310.1330.671–0.79
    Control380.7290.1190.69–0.769
    Femoral neckPolytherapy520.9380.15070.896–0.98
    Carbamazepine monotherapy330.887**0.1740.825–0.949
    Valproate monotherapy220.9740.1630.901–1.046
    Control381.0040.1020.971–1.038
    Total hipPolytherapy520.8130.1610.768–0.857
    Carbamazepine monotherapy330.7620.2130.686–0.838
    Valproate monotherapy220.8280.2170.732–0.925
    Control380.8690.1410.823–0.915
    • ↵* P < 0.01 compared with control.

    • CI = confidence interval.

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Journal of Nuclear Medicine Technology: 41 (3)
Journal of Nuclear Medicine Technology
Vol. 41, Issue 3
September 1, 2013
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Antiepileptic Treatment Is Associated with Bone Loss: Difference in Drug Type and Region of Interest
Hooman Salimipour, Sara Kazerooni, Mohammad Seyedabadi, Iraj Nabipour, Reza Nemati, Darioush Iranpour, Majid Assadi
Journal of Nuclear Medicine Technology Sep 2013, 41 (3) 208-211; DOI: 10.2967/jnmt.113.124685
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Keywords

  • bone mineral density (BMD)
  • antiepileptic drugs (AEDs)
  • convulsion
  • dual-energy x-ray absorptiometry (DXA)
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Antiepileptic Treatment Is Associated with Bone Loss: Difference in Drug Type and Region of Interest
Hooman Salimipour, Sara Kazerooni, Mohammad Seyedabadi, Iraj Nabipour, Reza Nemati, Darioush Iranpour, Majid Assadi
Journal of Nuclear Medicine Technology Sep 2013, 41 (3) 208-211; DOI: 10.2967/jnmt.113.124685

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