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Journal of Nuclear Medicine Technology

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Research ArticleIMAGING

Receiver-Operating-Characteristic Analysis of an Automated Program for Analyzing Striatal Uptake of 123I-Ioflupane SPECT Images: Calibration Using Visual Reads

Phillip Hsin Kuo, Ryan Avery, Elizabeth Krupinski, Hong Lei, Adam Bauer, Scott Sherman, Natalie McMillan, John Seibyl and George Zubal
Journal of Nuclear Medicine Technology March 2013, 41 (1) 26-31; DOI: https://doi.org/10.2967/jnmt.112.114827
Phillip Hsin Kuo
1Medical Imaging/Radiology and Neurology, University of Arizona, Tucson, Arizona
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Ryan Avery
1Medical Imaging/Radiology and Neurology, University of Arizona, Tucson, Arizona
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Elizabeth Krupinski
2Imaging Sciences, Institute for Neurodegenerative Disorders, New Haven, Connecticut; and
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Hong Lei
1Medical Imaging/Radiology and Neurology, University of Arizona, Tucson, Arizona
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Adam Bauer
1Medical Imaging/Radiology and Neurology, University of Arizona, Tucson, Arizona
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Scott Sherman
1Medical Imaging/Radiology and Neurology, University of Arizona, Tucson, Arizona
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Natalie McMillan
1Medical Imaging/Radiology and Neurology, University of Arizona, Tucson, Arizona
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John Seibyl
2Imaging Sciences, Institute for Neurodegenerative Disorders, New Haven, Connecticut; and
3Yale University School of Medicine, New Haven, Connecticut
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George Zubal
2Imaging Sciences, Institute for Neurodegenerative Disorders, New Haven, Connecticut; and
3Yale University School of Medicine, New Haven, Connecticut
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Figures

  • FIGURE 1.
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    FIGURE 1.

    Example of final report page from analysis of subject A, documenting SBRs for right caudate (Caud) and putamen (Puta) as well as for left caudate and putamen (1.17, 1.10, 1.80, and 1.25, respectively). Average (ave) of these 4 values is shown as 1.33 in top right corner. Placement of caudate and putamen small white ROIs is shown superimposed on summed slices containing stratum. Large red crescent ROI is used to determine nonspecific background count density. Central vertical dark line drawn in upper half of image is used as check to ensure that left and right striata were correctly localized during automated processing.

  • FIGURE 2.
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    FIGURE 2.

    Summary report showing statistics from ROC analysis of 94 patients using lowest putamen SBR calculated by OSA as variable, compared with classification from majority consensus of 3 expert readers. Table at bottom shows sensitivity and specificity for each cutoff criterion with their associated 95% confidence intervals (CI) and likelihood ratios (LR).

  • FIGURE 3.
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    FIGURE 3.

    Scatterplot showing OSA values for 3 categories of visual read interpretations: normal indicates unanimous consensus of normal scan (n = 29), abnormal indicates unanimous consensus of dopaminergic deficit (n = 59), and discordant indicates no unanimous consensus (n = 13).

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Journal of Nuclear Medicine Technology: 41 (1)
Journal of Nuclear Medicine Technology
Vol. 41, Issue 1
March 1, 2013
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Receiver-Operating-Characteristic Analysis of an Automated Program for Analyzing Striatal Uptake of 123I-Ioflupane SPECT Images: Calibration Using Visual Reads
Phillip Hsin Kuo, Ryan Avery, Elizabeth Krupinski, Hong Lei, Adam Bauer, Scott Sherman, Natalie McMillan, John Seibyl, George Zubal
Journal of Nuclear Medicine Technology Mar 2013, 41 (1) 26-31; DOI: 10.2967/jnmt.112.114827

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Receiver-Operating-Characteristic Analysis of an Automated Program for Analyzing Striatal Uptake of 123I-Ioflupane SPECT Images: Calibration Using Visual Reads
Phillip Hsin Kuo, Ryan Avery, Elizabeth Krupinski, Hong Lei, Adam Bauer, Scott Sherman, Natalie McMillan, John Seibyl, George Zubal
Journal of Nuclear Medicine Technology Mar 2013, 41 (1) 26-31; DOI: 10.2967/jnmt.112.114827
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Keywords

  • molecular neuroimaging
  • ioflupane
  • brain SPECT
  • DaTscan
  • software analysis
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