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Research ArticlePRACTICE GUIDELINE

SNMMI/EANM Guideline for Guideline Development 6.0

Dominique Delbeke, Arturo Chiti, Paul Christian, Jacques Darcourt, Kevin Donohoe, Albert Flotats, Bernd J. Krause and Henry D. Royal
Journal of Nuclear Medicine Technology December 2012, 40 (4) 283-289; DOI: https://doi.org/10.2967/jnmt.112.108787
Dominique Delbeke
1Vanderbilt University Medical Center, Nashville, Tennessee
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Arturo Chiti
2Istituto Clinico Humanitas, Milan, Italy
Roles: (Cochairs)
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Paul Christian
3University of Utah, Salt Lake City, Utah
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Jacques Darcourt
4Centre Antoine Lacassagne, Nice, France
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Kevin Donohoe
5Beth Israel Deaconess Medical Center, Boston, Massachusetts
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Albert Flotats
6San Pau Hospital, Barcelona, Spain
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Bernd J. Krause
7University Rostock, Rostock, Germany; and
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Henry D. Royal
8Mallinckrodt Institute of Radiology, St. Louis, Missouri
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  • Article
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Article Figures & Data

Tables

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    TABLE 1

    Radiation Dosimetry in Adults

    Administered activityLargest radiation doseEffective dose*
    RadiopharmaceuticalMBqmCiOrganmGy/MBqrad/mCimSv/MBqrem/mCi
    99mTc-MAA†40–1501.1–4.1Lung0.0670.250.0110.041
    99mTc-DTPA‡20–400.54–1.1Bladder0.0470.170.00610.023
    133Xe§200–7505.4–20Lung0.00110.00410.000710.0026
    81mKr‖40–4001.1–11Lung0.000210.000780.0000270.0001
    • ↵* Data are from (3).

    • ↵† Data are from (2), page 224.

    • ↵‡ Data are from (2), page 218.

    • ↵§ Data are from (2), page 345, rebreathing for 5 min.

    • ↵‖ Data are from (2), page 160.

    • View popup
    TABLE 2

    Radiation Dosimetry in Children (5 Years Old)

    Administered activityLargest radiation doseEffective dose
    RadiopharmaceuticalMBq/kgmCi/kgOrganmGy/MBqrad/mCimSv/MBqrem/mCi
    99mTc MAA*0.5–20.014–0.054Lung0.210.780.0380.14
    99mTc DTPA†0.4–0.60.011–0.016Bladder0.120.440.0200.074
    133Xe‡10–120.27–0.32Lung0.00370.0140.00270.010
    81mKr§0.5–50.014–0.14Lung0.000680.00250.0000880.00033
    • ↵* Data are from (2), page 224.

    • ↵† Data are from (2), page 218.

    • ↵‡ Data are from (2), page 345, rebreathing for 5 min.

    • ↵§ Data are from (2), page 160.

    • View popup
    TABLE 3

    99mTc MAA: Dose Estimates to the Fetus

    Fetal dose
    Stage of gestationmGy/MBqrad/mCimGy*rad*
    Early0.00280.0100.11–0.420.011–0.042
    3 mo0.00400.0150.16–0.600.016–0.060
    6 mo0.00500.0180.20–0.750.020–0.075
    9 mo0.00400.0150.16–0.600.016–0.060
    • ↵* Maternal administered activity, 40–150 MBq (1.1–1.4 mCi).

    • Data are from Russell et al. (7). No information about possible placental crossover of this compound was available for use in estimating fetal doses.

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    TABLE 4

    99mTc DTPA Aerosol: Dose Estimates to the Fetus

    Fetal dose
    Stage of gestationmGy/MBqrad/mCimGy*rad*
    Early0.00580.0210.12–0.230.012–0.023
    3 mo0.00430.0160.086–0.170.0086–0.017
    6 mo0.00230.00850.046–0.0920.0046–0.0092
    9 mo0.00300.0110.060–0.120.0060–0.012
    • ↵* Maternal administered activity, 20–40 MBq (0.54–1.1 mCi).

    • Data are from Russell et al. (7). Information about possible placental crossover of this compound was available and was considered in estimates of fetal doses.

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    TABLE 5

    133Xe: Dose Estimates to the Fetus

    Fetal dose
    Stage of gestationmGy/MBqrad/mCimGy*rad*
    Early0.000250.000920.050–0.190.0050–0.019
    3 mo0.0000290.000110.0058–0.0220.00058–0.0022
    6 mo0.0000210.0000780.0042–0.0160.00042–0.0016
    9 mo0.0000160.0000590.0032–0.010.00032–0.0012
    • ↵* Maternal administered activity, 200–750 MBq (5.4–20 mCi).

    • Data are from Russell et al. (7). No information about possible placental crossover of this compound was available for use in estimating fetal doses.

    • View popup
    TABLE 6

    81mKr: Dose Estimates to the Fetus

    Fetal dose
    Stage of gestationmGy/MBqrad/mCimGy*rad*
    Early1.8 × 10−76.7 × 10−77.2 × 10−6 to 7.2 × 10−57.2 × 10−5 to 7.2 × 10−6
    3 mo1.8 × 10−76.7 × 10−77.2 × 10−6 to 7.2 × 10−57.2 × 10−5 to 7.2 × 10−6
    6 mo2.8 × 10−71.0 × 10−61.1 × 10−5 to 1.1 × 10−41.1 × 10−6 to 1.1 × 10−5
    9 mo3.4 × 10−71.3 × 10−61.4 × 10−5 to 1.4 × 10−41.4 × 10−6 to 1.4 × 10−5
    • ↵* Maternal administered activity 40–400 MBq (1.1–11 mCi).

    • Dose estimates to the fetus were not provided by Russell et al. (7) but were estimated using kinetic data in ICRP 53. No information about possible placental crossover of this compound was available for use in estimating fetal doses.

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Journal of Nuclear Medicine Technology: 40 (4)
Journal of Nuclear Medicine Technology
Vol. 40, Issue 4
December 1, 2012
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SNMMI/EANM Guideline for Guideline Development 6.0
Dominique Delbeke, Arturo Chiti, Paul Christian, Jacques Darcourt, Kevin Donohoe, Albert Flotats, Bernd J. Krause, Henry D. Royal
Journal of Nuclear Medicine Technology Dec 2012, 40 (4) 283-289; DOI: 10.2967/jnmt.112.108787

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SNMMI/EANM Guideline for Guideline Development 6.0
Dominique Delbeke, Arturo Chiti, Paul Christian, Jacques Darcourt, Kevin Donohoe, Albert Flotats, Bernd J. Krause, Henry D. Royal
Journal of Nuclear Medicine Technology Dec 2012, 40 (4) 283-289; DOI: 10.2967/jnmt.112.108787
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  • Article
    • PREAMBLE
    • I. INTRODUCTION
    • II. GOALS
    • III. DEFINITIONS
    • IV. METHODOLOGY
    • V. FORMAT OF GUIDELINES
    • APPENDIX
    • Acknowledgments
    • VIII. APPROVAL
    • Footnotes
    • VII. REFERENCES
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