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Journal of Nuclear Medicine Technology

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Research ArticleINSTRUMENTATION

Rotation Radius Dependence of 123I-FP-CIT and 123I-IBZM SPECT Uptake Ratios: A Monte Carlo Study

Anne Larsson, Susanna Jakobson Mo and Katrine Riklund
Journal of Nuclear Medicine Technology December 2012, 40 (4) 249-254; DOI: https://doi.org/10.2967/jnmt.112.108555
Anne Larsson
1Department of Radiation Sciences, Radiation Physics, Umeå University, Umeå, Sweden; and
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Susanna Jakobson Mo
2Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
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Katrine Riklund
2Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Umeå, Sweden
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  • FIGURE 1.
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    FIGURE 1.

    ROIs used by ROI method, applied on high-uptake-ratio image (rotation radius, 15 cm). ROIs are applied on 12-mm-thick slab through striatal and occipital region.

  • FIGURE 2.
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    FIGURE 2.

    Correction factors for high (A) and low (B) uptake ratios measured with in-house ROI method. R is rotation radius measured in centimeters.

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    FIGURE 3.

    VOIs used by EXINI dat, demonstrated on high-uptake-ratio image (rotation radius, 17 cm). Caudate and putaminal VOIs are presented together with whole-brain background VOI, including occipital VOI.

  • FIGURE 4.
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    FIGURE 4.

    Correction factors for high (A) and low (B) uptake ratios measured with EXINI dat software. R is rotation radius measured in centimeters.

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    TABLE 1

    Activity Concentrations in 123I-IBZM Phantom

    StructureActivity concentration
    Gray matter62
    White matter54
    Cerebellum43
    Striatum170
    Hippocampus128
    Globus pallidus108
    Thalamus68
    Amygdala68
    Pituitary gland70
    Soft tissues outside brain13
    Ventricles0
    • An arbitrary unit can be assumed since only relative ratios are of importance for analyses in this study.

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Journal of Nuclear Medicine Technology: 40 (4)
Journal of Nuclear Medicine Technology
Vol. 40, Issue 4
December 1, 2012
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Rotation Radius Dependence of 123I-FP-CIT and 123I-IBZM SPECT Uptake Ratios: A Monte Carlo Study
Anne Larsson, Susanna Jakobson Mo, Katrine Riklund
Journal of Nuclear Medicine Technology Dec 2012, 40 (4) 249-254; DOI: 10.2967/jnmt.112.108555

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Rotation Radius Dependence of 123I-FP-CIT and 123I-IBZM SPECT Uptake Ratios: A Monte Carlo Study
Anne Larsson, Susanna Jakobson Mo, Katrine Riklund
Journal of Nuclear Medicine Technology Dec 2012, 40 (4) 249-254; DOI: 10.2967/jnmt.112.108555
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Keywords

  • SPECT
  • rotation radius
  • 123I
  • FP-CIT
  • IBZM
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