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Research ArticleRADIOPHARMACY

Experiences with Citrate Rather Than Heparin as an Anticoagulant for 18F-FDG Labeling of Leukocytes

Charlotte Eldjarn, Merethe Wigen Andersen, Randi Moen Forfang, Signe E. Hagve and Kjell Rootwelt
Journal of Nuclear Medicine Technology December 2011, 39 (4) 312-316; DOI: https://doi.org/10.2967/jnmt.110.085464
Charlotte Eldjarn
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Merethe Wigen Andersen
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Randi Moen Forfang
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Signe E. Hagve
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Kjell Rootwelt
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  • FIGURE 1.
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    FIGURE 1.

    Normal deposition of 18F-FDG–labeled leukocytes in spleen, liver, and bone marrow of healthy control. Faint uptake in brain and heart was caused by 18F-FDG eluted from WBCs. (A) Anterior view from volume-reconstructed image (maximum-intensity-projection image). (B) Coronal section through spine from coregistered PET/CT images.

  • FIGURE 2.
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    FIGURE 2.

    Pathologic deposition of 18F-FDG–labeled leukocytes in rectum/anal canal (arrows) and in lungs, particularly upper part of left lung, in patient with fever of unknown origin. (A) Anterior maximum-intensity-projection image. (B) Sagittal section through spine from coregistered PET/CT images. (C) Transaxial section through upper part of thorax from coregistered PET/CT images. (D) Transaxial section through lower pelvis from coregistered PET/CT images.

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    FIGURE 3.

    PET/CT with 18F-FDG–labeled WBCs for patient with recurrent sepsis and melena. Markedly increased uptake in coil-treated iliac artery aneurysm corresponded to WBC deposition extending proximal to coil, in parallel with common iliac artery, toward bifurcation. Transaxial section at this level showed air bubble in WBC deposition and apparently in sigmoid colon loop, indicating fistula between abscess and colon. No deposition corresponded to stent–graft to external iliac artery, but increased uptake indicated incidental infection in right tonsillar region. (A) Anterior maximum-intensity-projection image showing pelvic and tonsillar pathologies (arrows). (B) Coronal section through coil-treated iliac aneurysm (arrow) from coregistered PET/CT images. (C) Transaxial section through coil-treated iliac aneurysm (arrow) from coregistered PET/CT images. (D) Transaxial section through tonsillar region (arrow) from coregistered PET/CT images.

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Journal of Nuclear Medicine Technology: 39 (4)
Journal of Nuclear Medicine Technology
Vol. 39, Issue 4
December 1, 2011
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Experiences with Citrate Rather Than Heparin as an Anticoagulant for 18F-FDG Labeling of Leukocytes
Charlotte Eldjarn, Merethe Wigen Andersen, Randi Moen Forfang, Signe E. Hagve, Kjell Rootwelt
Journal of Nuclear Medicine Technology Dec 2011, 39 (4) 312-316; DOI: 10.2967/jnmt.110.085464

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Experiences with Citrate Rather Than Heparin as an Anticoagulant for 18F-FDG Labeling of Leukocytes
Charlotte Eldjarn, Merethe Wigen Andersen, Randi Moen Forfang, Signe E. Hagve, Kjell Rootwelt
Journal of Nuclear Medicine Technology Dec 2011, 39 (4) 312-316; DOI: 10.2967/jnmt.110.085464
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