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Research ArticleRADIOPHARMACY

Survey of the Performance of Commercial Dose Calibrators for Measurement of 123I Activity

Arnold F. Jacobson, Robert Centofanti, Olakiitan I. Babalola and Brian Dean
Journal of Nuclear Medicine Technology December 2011, 39 (4) 302-306; DOI: https://doi.org/10.2967/jnmt.111.089235
Arnold F. Jacobson
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Robert Centofanti
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Olakiitan I. Babalola
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Brian Dean
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  • FIGURE 1.
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    FIGURE 1.

    Schematic representation of procedures for determination of CFs. Vial CF = (calibrated vial activity × decay factor)/assayed vial activity. Syringe CF = syringe activity (calibrated vial activity − residual vial activity after syringe withdrawal)/assayed syringe activity. *Syringe and second vial assays were decay-corrected to time of first vial assay.

  • FIGURE 2.
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    FIGURE 2.

    Distribution of glass vial CFs for 167 dose calibrators tested without copper sleeves. CFv = vial CF.

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    FIGURE 3.

    Distribution of 10-mL plastic syringe CFs for 167 dose calibrators tested without copper sleeves. CFs = syringe CF.

Tables

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    TABLE 1

    Characterization of 177 Dose Calibrators Tested

    ManufacturerNo. of modelsNo. of units
    Biodex424
    Capintec19127
    Empos Ltd.11
    Medisystem12
    MIE Medical Imaging Electronics GmbH11
    Nuclear Associates11
    Nuklear Medizintechnik49
    PTW Freiburg GmbH36
    Radcal11
    Syncor11
    Veenstra34
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    TABLE 2

    CF Summary for 10-mL Glass Vials

    No copper sleeveCopper sleeve
    ContainerNo.Mean vial CFSDNo.Mean vial CFSD
    10-mL vial1671.278 (range, 0.823–1.757)0.152101.538 (range, 0.931–2.566)0.697
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    TABLE 3

    CFs for Measurements Using Copper Sleeves

    Dose calibratorVial CFSyringe CF (10 mL)Difference (syringe CF − vial CF)Manufacturer and model
    11.288Not done—Biodex Atomlab 100
    21.0521.0070.045Capintec CRC-15R
    31.6631.6280.035Capintec CRC-15R
    42.3952.3600.035Capintec CRC-15R
    50.9780.9440.034Capintec CRC-15R
    60.9760.9710.005Amersham Radioisotope Calibrator (ARC)-150
    72.5302.4610.069Capintec CRC-15R
    82.5662.4920.074Capintec CRC-15R
    90.9310.8870.044Capintec CRC-12R
    101.0041.0700.064Capintec CRC-15R
    Mean1.5381.5360.002—
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    TABLE 4

    CF Summary for Plastic Syringes

    No copper sleeveCopper sleeve
    ContainerNo.Mean syringe CFSDNo.Mean syringe CFSD
    10-mL syringe1670.811 (range, 0.472–1.052)0.09691.536 (range, 0.877–2.492)0.730
    5-mL syringe230.815 (range, 0.722–1.027)0.07221.030 (range, 1.020–1.040)—
    3-mL syringe170.792 (range, 0.728–0.935)0.05220.984 (range, 0.963–1.005)—
    • View popup
    TABLE 5

    Vial CF by Dose Calibrator Manufacturer: No Copper Sleeve

    ManufacturerNo. of unitsMean vial CF
    Biodex231.438 (range, 1.064–1.626)
    Capintec1181.274 (range, 0.823–1.757)
    Empos Ltd.10.988
    Medisystem20.922 (range, 0.890–0.954)
    MIE Medical Imaging Electronics GmbH11.312
    Nuclear Associates11.298
    Nuklear Medizintechnik91.193 (range, 0.977–1.534)
    PTW Freiburg GmbH61.069 (range, 0.917–1.207)
    Radcal11.227
    Syncor11.224
    Veenstra41.210 (range, 0.996–1.332)
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Journal of Nuclear Medicine Technology: 39 (4)
Journal of Nuclear Medicine Technology
Vol. 39, Issue 4
December 1, 2011
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Survey of the Performance of Commercial Dose Calibrators for Measurement of 123I Activity
Arnold F. Jacobson, Robert Centofanti, Olakiitan I. Babalola, Brian Dean
Journal of Nuclear Medicine Technology Dec 2011, 39 (4) 302-306; DOI: 10.2967/jnmt.111.089235

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Survey of the Performance of Commercial Dose Calibrators for Measurement of 123I Activity
Arnold F. Jacobson, Robert Centofanti, Olakiitan I. Babalola, Brian Dean
Journal of Nuclear Medicine Technology Dec 2011, 39 (4) 302-306; DOI: 10.2967/jnmt.111.089235
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