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Research ArticlePRACTICE GUIDELINES

SNM Practice Guideline for Hepatobiliary Scintigraphy 4.0

Mark Tulchinsky, Brian W. Ciak, Dominique Delbeke, Andrew Hilson, Kelly Anne Holes-Lewis, Michael G. Stabin and Harvey A. Ziessman
Journal of Nuclear Medicine Technology December 2010, 38 (4) 210-218; DOI: https://doi.org/10.2967/jnmt.110.082289
Mark Tulchinsky
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Brian W. Ciak
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Dominique Delbeke
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Andrew Hilson
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Kelly Anne Holes-Lewis
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Michael G. Stabin
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Harvey A. Ziessman
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Tables

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    TABLE 1

    Expected GBEF for Tested Techniques

    Sincalide dose (μg/kg)Time of infusion (min)Mean GBEF ± SD (%)GBEF range (%)No. of healthy individuals studiedReference
    0.04343 ± 2615–8812(82)
    0.02335 ± 1717–596(82)
    0.02356 ± 270–10023(84)
    0.01346 ± 2012–7420(86)
    0.011076 ± 1637–9613(87)*
    0.021576 ± 2232–9815(88)
    0.021557 ± 2922–9860(85)
    0.013064 ± 2026–9514(84)
    0.023070 ± 2217–9723(84)
    0.023071 ± 258–9960(85)
    0.0154575 ± 12>40†40(3)
    0.016068 ± 1615–8820(86)
    0.026084 ± 1638–10060(85)
    • ↵* Subjects were prescreened with a 3-min sincalide stimulation, and those with GBEF < 35% were excluded.

    • ↵† 95% confidence limits.

    • View popup
    TABLE 2

    Radiation Dosimetry in Adults

    Administered activityLargest radiation doseEffective dose
    RadiopharmaceuticalMBqmCiOrganmGy/MBqrad/mCimSv/MBqrem/mCi
    99mTc-disofenin or 99mTc-mebrofenin56–180 intravenously1.5–5.0Gallbladder wall0.110.410.0170.063
    • *Data are from (95).

    • View popup
    TABLE 3

    Radiation Dosimetry in Children

    Administered activityLargest radiation doseEffective dose
    RadiopharmaceuticalMBq/kgmCi/kgAge(y)OrganmGy/MBqrad/mCimSv/MBqrem/mCi
    99mTc-disofenin1.85 intravenously0.051Gallbladder wall0.953.50.100.37
    5ULI0.291.10.0450.17
    99mTc-mebrofenin1.85 intravenously0.0510ULI0.180.670.0290.11
    15Gallbladder wall0.120.440.0210.078
    • *Data are from (95).

    • ULI = upper large intestine.

    • View popup
    TABLE 4

    Radiation Dosimetry in the Pregnant or Potentially Pregnant Patient

    Fetal dose
    Stage of gestationmGy/MBqrad/mCi
    Early0.0170.063
    3 mo0.0150.056
    6 mo0.0120.044
    9 mo0.00670.025
    • Dose estimates to fetus are from Russell et al. (96) and allow a physician to make the best possible informed recommendation to an individual patient. However, no information about possible placental crossover of hepatobiliary compounds is available.

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Journal of Nuclear Medicine Technology: 38 (4)
Journal of Nuclear Medicine Technology
Vol. 38, Issue 4
December 1, 2010
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SNM Practice Guideline for Hepatobiliary Scintigraphy 4.0
Mark Tulchinsky, Brian W. Ciak, Dominique Delbeke, Andrew Hilson, Kelly Anne Holes-Lewis, Michael G. Stabin, Harvey A. Ziessman
Journal of Nuclear Medicine Technology Dec 2010, 38 (4) 210-218; DOI: 10.2967/jnmt.110.082289

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SNM Practice Guideline for Hepatobiliary Scintigraphy 4.0
Mark Tulchinsky, Brian W. Ciak, Dominique Delbeke, Andrew Hilson, Kelly Anne Holes-Lewis, Michael G. Stabin, Harvey A. Ziessman
Journal of Nuclear Medicine Technology Dec 2010, 38 (4) 210-218; DOI: 10.2967/jnmt.110.082289
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  • Article
    • Abstract
    • PREAMBLE
    • I. INTRODUCTION
    • II. GOALS
    • III. DEFINITIONS
    • IV. COMMON CLINICAL INDICATIONS
    • V. QUALIFICATIONS AND RESPONSIBILITIES OF PERSONNEL
    • VI. THE PROCEDURE/SPECIFICATION OF THE EXAMINATION
    • VII. DOCUMENTATION/REPORTING
    • VIII. EQUIPMENT SPECIFICATIONS
    • IX. QUALITY CONTROL AND IMPROVEMENT, SAFETY, INFECTION CONTROL, AND PATIENT EDUCATION CONCERNS
    • X. RADIATION SAFETY IN IMAGING
    • Acknowledgments
    • XIII. APPROVAL
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

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  • Use of a Fatty Meal Cholecystagogue Protocol in Hepatobiliary Scintigraphy for Chronic Functional Gallbladder Disease
  • Fatty Meal Hepatobiliary Scintigraphy for Gallbladder Ejection Fraction Determination
  • Hepatobiliary Imaging
  • Cholescintigraphy for Differentiation of True Duodenal Obstruction from Pseudo Obstruction
  • Regarding Pharmacology, Part 3A
  • Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues
  • Hepatobiliary Scintigraphy in 2014
  • Hepatobiliary Scintigraphy in 2014
  • The SNM Practice Guideline on Hepatobiliary Scintigraphy
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