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Research ArticleIMAGING

Myocardial SPECT Images for Diagnosis of Pulmonary Hypertension and Right Ventricular Hypertrophy

Reza M. Mazraeshahi, Jeffrey Striet, Ryan C. Oeltgen and Myron C. Gerson
Journal of Nuclear Medicine Technology December 2010, 38 (4) 175-180; DOI: https://doi.org/10.2967/jnmt.110.080200
Reza M. Mazraeshahi
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Jeffrey Striet
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Ryan C. Oeltgen
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Myron C. Gerson
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  • FIGURE 1.
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    FIGURE 1.

    Selection of region of interest in lateral free wall.

  • FIGURE 2.
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    FIGURE 2.

    Correlation of RV/LV ratio with pulmonary artery (PA) systolic pressure in non–attenuation-corrected images.

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    FIGURE 3.

    Correlation of RV/LV ratio with right ventricular wall thickness in non–attenuation-corrected images.

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    FIGURE 4.

    Receiver operator analysis using RV/LV uptake ratio, on non–attenuation-corrected images, for detecting significant pulmonary hypertension.

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    FIGURE 5.

    Correlation of RV/LV ratio with pulmonary artery (PA) systolic pressure on attenuation-corrected images.

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    FIGURE 6.

    Correlation of RV/LV ratio with right ventricular wall thickness on attenuation-corrected images.

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    TABLE 1

    Baseline Characteristics

    CharacteristicNumber
    History of pulmonary diseases6 (18%)
    History of hypertension23 (70%)
    History of diabetes mellitus8 (24%)
    History of heart failure13 (39%)
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    TABLE 2

    Imaging Findings

    ParameterMean ± SDRange
    Estimated pulmonary artery systolic pressure (mm Hg)42 ± 1620–79
    Right ventricular thickness (mm)4.9 ± 1.12.5–7.3
    Ejection fraction by echocardiography (%)48 ± 1910–75
    Ejection fraction by SPECT (%)55 ± 2011–84
    RV/LV uptake ratio (non–attenuation-corrected)0.36 ± 0.10.22–0.74
    RV/LV uptake ratio (attenuation-corrected)0.47 ± 0.10.3–0.77
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    TABLE 3

    Sensitivity and Specificity of RV/LV Ratio for Detection of Significant Pulmonary Hypertension

    RV/LV ratioSensitivitySpecificityPositive likelihood ratio
    0.3085%32%1.25
    0.3572%70%2.4
    0.3864%90%6.4
    0.464%95%12.8
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    TABLE 4

    RV/LV Uptake Ratio Among Patients with Abnormal and Normal Estimated Systolic Pulmonary Artery Pressures

    ParameterSignificant elevation (estimated PAP ≥ 40 mm Hg)No significant elevation (estimated PAP < 40 mm Hg)P
    RV/LV uptake ratio (non–attenuation-corrected)0.43 ± 0.120.32 ± 0.050.002
    RV/LV uptake ratio (attenuation-corrected)0.5 ± 0.090.45 ± 0.110.2
    • PAP = pulmonary artery pressure.

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Journal of Nuclear Medicine Technology: 38 (4)
Journal of Nuclear Medicine Technology
Vol. 38, Issue 4
December 1, 2010
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Myocardial SPECT Images for Diagnosis of Pulmonary Hypertension and Right Ventricular Hypertrophy
Reza M. Mazraeshahi, Jeffrey Striet, Ryan C. Oeltgen, Myron C. Gerson
Journal of Nuclear Medicine Technology Dec 2010, 38 (4) 175-180; DOI: 10.2967/jnmt.110.080200

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Myocardial SPECT Images for Diagnosis of Pulmonary Hypertension and Right Ventricular Hypertrophy
Reza M. Mazraeshahi, Jeffrey Striet, Ryan C. Oeltgen, Myron C. Gerson
Journal of Nuclear Medicine Technology Dec 2010, 38 (4) 175-180; DOI: 10.2967/jnmt.110.080200
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