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Research ArticleSPECIAL CONTRIBUTION

Advances in Pharmacologic Stress Agents: Focus on Regadenoson

Sara G. Johnson and Scott Peters
Journal of Nuclear Medicine Technology September 2010, 38 (3) 163-171; DOI: https://doi.org/10.2967/jnmt.109.065581
Sara G. Johnson
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Scott Peters
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  • FIGURE 1.
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    FIGURE 1.

    Reversal time of coronary vasodilation in high-affinity and low-affinity A2A agonists (21,34). Ki = dissociation constant of inhibitor; t0.5 = time to 50% reversal if coronary conductance increases in rat isolated perfused hearts. (Reprinted with permission of (34).)

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    FIGURE 2.

    Agreement rates of adenosine–adenosine and adenosine–regadenoson stress MPI studies with respect to extent of ischemia in combined ADVANCE MPI 1 and 2 study population (41). Data are median ± SE.

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    FIGURE 3.

    Administration of regadenoson. *Aminophylline may be given 1–2 min after injection of isotope to reverse persistent or severe side effects.

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    TABLE 1.

    Definitions of Common Pharmacologic Terms

    TermDefinition
    AgonistA molecule that binds to a receptor and elicits a response by the cell
    AntagonistA molecule that binds to a receptor, but rather than causing a response, blocks the binding of an agonist, so preventing the response
    AffinityThe tightness with which an agonist/antagonist binds to a receptor (described using the dissociation constant)
    SelectivityActivity of an agonist against a limited number of receptors
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Journal of Nuclear Medicine Technology: 38 (3)
Journal of Nuclear Medicine Technology
Vol. 38, Issue 3
September 1, 2010
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Advances in Pharmacologic Stress Agents: Focus on Regadenoson
Sara G. Johnson, Scott Peters
Journal of Nuclear Medicine Technology Sep 2010, 38 (3) 163-171; DOI: 10.2967/jnmt.109.065581

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Advances in Pharmacologic Stress Agents: Focus on Regadenoson
Sara G. Johnson, Scott Peters
Journal of Nuclear Medicine Technology Sep 2010, 38 (3) 163-171; DOI: 10.2967/jnmt.109.065581
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  • Article
    • Abstract
    • PHARMACOLOGIC STRESS AGENTS
    • A2A RECEPTOR AGONISTS
    • REGADENOSON
    • PRACTICAL ASPECTS
    • CONCLUSION
    • Acknowledgments
    • REFERENCES
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