Evaluation of Zeta-Potential and Particle Size of Technetium 99mTc-Sulfur Colloid Subsequent to the Addition of Lidocaine and Sodium Bicarbonate

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
FIGURE 1.
(A and B) Comparison of zeta-potential over time for different preparations. (C) Comparison of cumulative data for different preparations.
Download figure
Open in new tab
Download powerpoint
FIGURE 2.
Changes in zeta-potential with time.

TABLE 1

Cumulative Data

Sample name	Zeta-Potential ± SD^* (mV^†)	Particle size (d.nm^‡)	Radiochemical purity (%)	pH
Unfiltered sulfur colloid	−8.27 ± 1.14	396–531	99.5	5.8
Filtered sulfur colloid	−5.09 ± 1.68	11–343	98.5	6.0
4.2% sodium bicarbonate with 2% lidocaine HCl	−3.01 ± 2.24	10–351	94.1	6.3
8.4% sodium bicarbonate with 2% lidocaine HCl	−4.09 ± 2.90	10–330	94.0	7.1

TABLE 2

Particle Size as Affected by pH-Adjusted Lidocaine

	Primary peak			Secondary peak			Tertiary peak
Sample name	d.nm^*	±SD^†	%	d.nm	±SD	%	d.nm	±SD	%
Filtered sulfur colloid	10.55	0.03536	63.2	343.5	53.53	27.1	60.84	29.94	7.6
4.2% sodium bicarbonate with 2% lidocaine HCl	159.6	73.75	69.2	44.08	9.482	20	9.04	0.3309	10.8
8.4% sodium bicarbonate with 2% lidocaine HCl	36.13	32.66	57.2	178.1	6.152	26	7.318	2.656	16.9
Unfiltered sulfur colloid	466.7	0	100	0	0	0	0	0	0