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OtherRADIOPHARMACY

Stability of Stabilized 99mTc-d,l-HMPAO Stored in Vials and Syringes

Maria del Carmen Plancha-Mansanet, Elisa Caballero-Calabuig, Jesús Félix-Fontestad, María Dolores Reyes-Ojeda, Pablo Sopena-Novales, Pedro Abreu-Sánchez, Maria del Carmen Cano-Terol and Ramón Sopena-Monforte
Journal of Nuclear Medicine Technology December 2008, 36 (4) 213-216; DOI: https://doi.org/10.2967/jnmt.108.053488
Maria del Carmen Plancha-Mansanet
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Elisa Caballero-Calabuig
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Jesús Félix-Fontestad
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María Dolores Reyes-Ojeda
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Pablo Sopena-Novales
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Pedro Abreu-Sánchez
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Maria del Carmen Cano-Terol
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Ramón Sopena-Monforte
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    FIGURE 1. 

    Percentage of RCP of stabilized 99mTc-d,l-HMPAO over time in both groups of labeling activities and forms of storage.

  • FIGURE 2. 
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    FIGURE 2. 

    Percentage of radiochemical impurities in stabilized 99mTc-d,l-HMPAO over time in vials and syringes (mean ± SD; n = 10).

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    TABLE 1

    Effect of Labeling Activity and Storage Form on RCP of Stabilized 99mTc-d,l-HMPAO over Time

    1,110 MBq2,600–3,700 MBq
    Time (h)VialSyringeNeedleVialSyringeNeedle
    093.1 ± 1.6NANA91.4 ± 1.0NANA
    292.1 ± 0.989.8 ± 2.174.2 ± 5.089.0 ± 1.485.9 ± 1.473.3 ± 8.5
    491.1 ± 1.088.7 ± 2.059.8 ± 5.185.3 ± 3.080.2 ± 3.157.1 ± 4.5
    • NA = not applicable.

    • Values represent percentage of RCP (mean ± SD); n = 10. P < 0.01 for vials between both groups of labeling activities at all times. P < 0.01 for syringes in both groups of labeling activities at 2 and 4 h. P < 0.01 between vials and syringes in both groups of labeling activities at 2 and 4 h. P < 0.01 between vials and needles in both groups of labeling activities at 2 and 4 h. P < 0.01 between syringes and needles in both groups of labeling activities at 2 and 4 h.

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    TABLE 2

    Effect of Labeling Activity and Storage Form on Radiochemical Impurities in Stabilized 99mTc-d,l-HMPAO in Vials and Syringes over Time

    1,110 MBq2,600–3,700 MBq
    99mTcO2 + secondary 99mTc-HMPAO99mTcO4−99mTcO2 + secondary 99mTc-HMPAO99mTcO4−
    Time (h)VialSyringeVialSyringeVialSyringeVialSyringe
    04.8 ± 0.9NA2.1 ± 0.9NA6.2 ± 1.2NA2.3 ± 0.7NA
    25.5 ± 0.96.2 ± 1.22.4 ± 0.54.0 ± 1.67.0 ± 1.48.1 ± 1.54.1 ± 1.26.0 ± 1.2
    46.1 ± 0.86.3 ± 0.92.8 ± 0.65.0 ± 1.78.6 ± 1.79.3 ± 1.96.2 ± 1.710.4 ± 2.5
    • NA = not applicable.

    • Values represent percentage of radiochemical impurities (mean ± SD); n = 10. P < 0.01 for 99mTcO2 + secondary 99mTc-HMPAO and 99mTcO4− between both groups of activities in vial and syringe at all times. P > 0.05 for 99mTcO4− between both groups of labeling activities in vial at t = 0.

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Journal of Nuclear Medicine Technology: 36 (4)
Journal of Nuclear Medicine Technology
Vol. 36, Issue 4
December 2008
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Stability of Stabilized 99mTc-d,l-HMPAO Stored in Vials and Syringes
Maria del Carmen Plancha-Mansanet, Elisa Caballero-Calabuig, Jesús Félix-Fontestad, María Dolores Reyes-Ojeda, Pablo Sopena-Novales, Pedro Abreu-Sánchez, Maria del Carmen Cano-Terol, Ramón Sopena-Monforte
Journal of Nuclear Medicine Technology Dec 2008, 36 (4) 213-216; DOI: 10.2967/jnmt.108.053488

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Stability of Stabilized 99mTc-d,l-HMPAO Stored in Vials and Syringes
Maria del Carmen Plancha-Mansanet, Elisa Caballero-Calabuig, Jesús Félix-Fontestad, María Dolores Reyes-Ojeda, Pablo Sopena-Novales, Pedro Abreu-Sánchez, Maria del Carmen Cano-Terol, Ramón Sopena-Monforte
Journal of Nuclear Medicine Technology Dec 2008, 36 (4) 213-216; DOI: 10.2967/jnmt.108.053488
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