RT Journal Article
SR Electronic
T1 Stability of Stabilized <sup>99m</sup>Tc-<span class="sc">d</span>,<span class="sc">l</span>-HMPAO Stored in Vials and Syringes
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 213
OP 216
DO 10.2967/jnmt.108.053488
VO 36
IS 4
A1 del Carmen Plancha-Mansanet, Maria
A1 Caballero-Calabuig, Elisa
A1 Félix-Fontestad, Jesús
A1 Reyes-Ojeda, María Dolores
A1 Sopena-Novales, Pablo
A1 Abreu-Sánchez, Pedro
A1 del Carmen Cano-Terol, Maria
A1 Sopena-Monforte, Ramón
YR 2008
UL http://tech.snmjournals.org/content/36/4/213.abstract
AB Our objective was to determine the stability of stabilized 99mTc-hexamethylpropylene amine oxime (99mTc-d,l-HMPAO) dispensed by vial and syringe, with the storage time and labeling activity varied. Methods: 99mTc-d,l-HMPAO was labeled according to the manufacturer's instructions, but with modification of the 99mTcO4Na activity. Two groups were prepared: 1,110 MBq (30 mCi) and 2,600–3,700 MBq (70.3–100 mCi). Five minutes after labeling, the radiochemical purity (RCP) of the vial content was determined. Afterward, the same activity was distributed into two 2-mL syringes and into the manufacturer's vial. In one of the syringes, the radiopharmaceutical stayed in contact with the needle for 4 h. At 2 and 4 h after labeling, the RCP of the vial and syringe content was checked and compared. Results: The mean RCP of stabilized 99mTc-d,l-HMPAO labeled with 1,110 MBq (30 mCi) and stored in a vial decreased from 93.1% at 5 min to 92.1% at 2 h and to 91.1% at 4 h. With storage in a syringe, the RCP decreased from 89.8% at 2 h to 88.7% at 4 h. This diminution increased for labeling with higher activities (2,600–3,700 MBq [70.3–100 mCi]), ranging from 91.4% at 5 min, 89.0% at 2 h, and 85.3% at 4 h in a vial and from 85.9% at 2 h to 80.2% in a syringe. 99mTcO2 and secondary 99mTc-HMPAO were the main impurities at t = 0. 99mTcO4− was an impurity that increased with time in both vials and syringes but significantly so in syringes. All these impurities were higher with labeling activities in the range of 2,600–3,700 MBq (70.3–100 mCi). Contact of the needle with 99mTc-d,l-HMPAO sharply decreased the RCP to 57.1% at 4 h. Conclusion: The RCP of stabilized 99mTc-d,l-HMPAO decreases significantly in both vials and syringes with high labeling activities. The product is less stable when stored in a syringe than in a vial. The fraction of dose in contact with the needle affects the RCP results.