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OtherNUCLEAR PHARMACY

The Effect of Vincristine on the Biodistribution of Technetium-99m DTPA, GHA, and DMSA in Balb/c Female Mice

Deise Mara M. Mattos, Maria Luisa Gomes, Rosimeire S. Freitas, Edson M. Boasquevisque, Valbert N. Cardoso, Emílio F. Paula and Mario Bernardo-Filho
Journal of Nuclear Medicine Technology December 2000, 28 (4) 271-274;
Deise Mara M. Mattos
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Maria Luisa Gomes
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Rosimeire S. Freitas
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Edson M. Boasquevisque
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Valbert N. Cardoso
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Emílio F. Paula
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Mario Bernardo-Filho
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    TABLE 1.

    Effect of Vincristine on the Biodistribution of Technetium-99m DMSA in Mice

    Organ% Uptake
    Control (n = 15)Treated (n = 15)
    Lung0.9470 ± 0.20502.2530 ± 0.4946
    Pancreas0.0443 ± 0.00740.0943 ± 0.0177
    Heart0.4258 ± 0.06600.8077 ± 0.1318
    Thyroid0.0479 ± 0.01430.0938 ± 0.0252
    Brain0.0990 ± 0.02400.2529 ± 0.0676
    Bone0.2198 ± 0.04000.4158 ± 0.0813
    Lymph node inguinal0.0513 ± 0.01490.1163 ± 0.0307
    Lymph node mesenteric0.0558 ± 0.01180.0888 ± 0.0263
    Uterus0.1644 ± 0.00390.1654 ± 0.0020
    Ovary0.1005 ± 0.02290.1017 ± 0.0231
    Spleen0.2104 ± 0.02830.2230 ± 0.0351
    Thymus0.0718 ± 0.01250.0841 ± 0.0200
    Kidney7.5642 ± 0.63626.9787 ± 1.0892
    Liver6.1344 ± 1.01506.5146 ± 0.6660
    Stomach0.4325 ± 0.04260.4759 ± 0.1160
    • View popup
    TABLE 2.

    Effect of Vincristine on the Biodistribution of Technetium-99m GHA in Mice

    Organ% Uptake
    Control (n = 15)Treated (n = 15)
    Uterus0.0926 ± 0.00480.0253 ± 0.0040
    Ovary0.0301 ± 0.00260.0105 ± 0.0013
    Spleen0.0662 ± 0.01150.0235 ± 0.0024
    Thymus0.0368 ± 0.00890.0111 ± 0.0019
    Lymph node inguinal0.2038 ± 0.01100.0277 ± 0.0057
    Lymph node mesenteric0.0832 ± 0.00550.0111 ± 0.0006
    Kidney3.4316 ± 0.31051.2583 ± 0.2581
    Heart0.1100 ± 0.00700.0655 ± 0.0137
    Lung0.3639 ± 0.01410.3544 ± 0.0198
    Liver0.4890 ± 0.03660.4738 ± 0.0537
    Pancreas0.0172 ± 0.00230.0170 ± 0.0028
    Stomach0.4384 ± 0.04770.4355 ± 0.0499
    Thyroid0.0484 ± 0.01000.0493 ± 0.0087
    Brain0.0483 ± 0.01330.0444 ± 0.0038
    Bone0.0348 ± 0.00330.0340 ± 0.0029
    • View popup
    TABLE 3.

    Effect of Vincristine on the Biodistribution of Technetium-99m DTPA in Mice

    Organ% Uptake
    Control (n = 15)Treated (n = 15)
    Thymus0.0103 ± 0.00860.0353 ± 0.0024
    Lymph node inguinal0.0141 ± 0.00270.0670 ± 0.0056
    Lymph node mesenteric0.0201 ± 0.00740.0481 ± 0.0125
    Ovary0.0107 ± 0.00740.0475 ± 0.0112
    Uterus0.0204 ± 0.00160.1350 ± 0.0098
    Spleen0.0134 ± 0.00680.0410 ± 0.0112
    Kidney0.1587 ± 0.04680.7891 ± 0.0115
    Heart0.0165 ± 0.00180.1632 ± 0.0691
    Stomach0.0334 ± 0.01920.2334 ± 0.0142
    Lung0.0272 ± 0.00950.4783 ± 0.0181
    Liver0.0668 ± 0.01220.3564 ± 0.0102
    Bone0.0162 ± 0.00360.1101 ± 0.0311
    Pancreas0.0194 ± 0.00180.0130 ± 0.0021
    Thyroid0.0871 ± 0.01230.0760 ± 0.0151
    Brain0.0610 ± 0.01320.0699 ± 0.0211
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Journal of Nuclear Medicine Technology: 28 (4)
Journal of Nuclear Medicine Technology
Vol. 28, Issue 4
December 1, 2000
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The Effect of Vincristine on the Biodistribution of Technetium-99m DTPA, GHA, and DMSA in Balb/c Female Mice
Deise Mara M. Mattos, Maria Luisa Gomes, Rosimeire S. Freitas, Edson M. Boasquevisque, Valbert N. Cardoso, Emílio F. Paula, Mario Bernardo-Filho
Journal of Nuclear Medicine Technology Dec 2000, 28 (4) 271-274;

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The Effect of Vincristine on the Biodistribution of Technetium-99m DTPA, GHA, and DMSA in Balb/c Female Mice
Deise Mara M. Mattos, Maria Luisa Gomes, Rosimeire S. Freitas, Edson M. Boasquevisque, Valbert N. Cardoso, Emílio F. Paula, Mario Bernardo-Filho
Journal of Nuclear Medicine Technology Dec 2000, 28 (4) 271-274;
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