Skip to main content

Main menu

  • Home
  • Content
    • Current
      • JNMT Supplement
    • Ahead of print
    • Past Issues
    • Continuing Education
    • JNMT Podcast
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNMT
    • Information for Authors
    • Assignment of Copyright
    • AQARA Requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNMT
    • JNM
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine Technology
  • SNMMI
    • JNMT
    • JNM
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine Technology

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • Continuing Education
    • JNMT Podcast
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNMT
    • Information for Authors
    • Assignment of Copyright
    • AQARA Requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Watch or Listen to JNMT Podcast
  • Visit SNMMI on Facebook
  • Join SNMMI on LinkedIn
  • Follow SNMMI on Twitter
  • Subscribe to JNMT RSS feeds
Radiopharmacy

Radiopharmaceutical Evaluation of Tc-99m Hydroxymethylene Diphosphonate

Walter Majewski, A. Michael Zimmer and Stewart M. Spies
Journal of Nuclear Medicine Technology March 1983, 11 (1) 23-25;
Walter Majewski
Northwestern University Medical School, Chicago, Illinois
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Michael Zimmer
Northwestern University Medical School, Chicago, Illinois
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stewart M. Spies
Northwestern University Medical School, Chicago, Illinois
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

The radiopharmaceutical purity and stability of Tc-99m hydroxymethylene diphosphonate were studied over a ten-week period using miniaturized chromatography to evaluate levels of both free pertechnetate and hydrolyzed reduced Tc-99m. Results showed good preparation stability up to 4 hr postformulation even when 400 mCi of activity was added. After 4 hr postformulation, some inconsistent radiopharmaceutical degradation was observed. Both old and new formulations of Tc-99m hydroxymethylene diphosphonate were very sensitive to air introduction. The new formulation was less sensitive to air oxidation because of higher stannous chloride and gentisic acid levels. We stress careful technique when dispensing Tc-99m hydroxymethylene diphosphonate in order to minimize any air introduction.

PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine Technology: 11 (1)
Journal of Nuclear Medicine Technology
Vol. 11, Issue 1
March 1, 1983
  • Table of Contents
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Radiopharmaceutical Evaluation of Tc-99m Hydroxymethylene Diphosphonate
(Your Name) has sent you a message from Journal of Nuclear Medicine Technology
(Your Name) thought you would like to see the Journal of Nuclear Medicine Technology web site.
Citation Tools
Radiopharmaceutical Evaluation of Tc-99m Hydroxymethylene Diphosphonate
Walter Majewski, A. Michael Zimmer, Stewart M. Spies
Journal of Nuclear Medicine Technology Mar 1983, 11 (1) 23-25;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Radiopharmaceutical Evaluation of Tc-99m Hydroxymethylene Diphosphonate
Walter Majewski, A. Michael Zimmer, Stewart M. Spies
Journal of Nuclear Medicine Technology Mar 1983, 11 (1) 23-25;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Miniaturized Radiochemical Purity Testing for 99mTc-HMPAO, 99mTc-HMDP, and 99mTc-Tetrofosmin
  • Changes in Patterns of 99mTc-Macroaggregated Albumin Use Between 2000 and 2015
  • Absorbed Radiation Doses to Staff After Implementation of a Radiopharmacy Clean Room
Show more Radiopharmacy

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire