RT Journal Article SR Electronic T1 Radiopharmaceutical Evaluation of Tc-99m Hydroxymethylene Diphosphonate JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 23 OP 25 VO 11 IS 1 A1 Majewski, Walter A1 Zimmer, A. Michael A1 Spies, Stewart M. YR 1983 UL http://tech.snmjournals.org/content/11/1/23.abstract AB The radiopharmaceutical purity and stability of Tc-99m hydroxymethylene diphosphonate were studied over a ten-week period using miniaturized chromatography to evaluate levels of both free pertechnetate and hydrolyzed reduced Tc-99m. Results showed good preparation stability up to 4 hr postformulation even when 400 mCi of activity was added. After 4 hr postformulation, some inconsistent radiopharmaceutical degradation was observed. Both old and new formulations of Tc-99m hydroxymethylene diphosphonate were very sensitive to air introduction. The new formulation was less sensitive to air oxidation because of higher stannous chloride and gentisic acid levels. We stress careful technique when dispensing Tc-99m hydroxymethylene diphosphonate in order to minimize any air introduction.