Skip to main content

Main menu

  • Home
  • Content
    • Current
      • JNMT Supplement
    • Ahead of print
    • Past Issues
    • Continuing Education
    • JNMT Podcast
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNMT
    • Information for Authors
    • Assignment of Copyright
    • AQARA Requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNMT
    • JNM
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine Technology
  • SNMMI
    • JNMT
    • JNM
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine Technology

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • Continuing Education
    • JNMT Podcast
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNMT
    • Information for Authors
    • Assignment of Copyright
    • AQARA Requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Watch or Listen to JNMT Podcast
  • Visit SNMMI on Facebook
  • Join SNMMI on LinkedIn
  • Follow SNMMI on Twitter
  • Subscribe to JNMT RSS feeds
Imaging

Effects of Cyclosporine in Lowering Red Blood Cell Technetium-99m Labeling Efficiency

Mel L. Allen, Alan L. McPherson, Bernie J. Mertes, David F. Preston and Ralph G. Robinson
Journal of Nuclear Medicine Technology September 1990, 18 (3) 191-193;
Mel L. Allen
Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kansas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alan L. McPherson
Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kansas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bernie J. Mertes
Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kansas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David F. Preston
Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kansas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralph G. Robinson
Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kansas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Cyclosporine, an immunosuppressant drug taken by many transplant patients, has been found to significantly lower red blood cell (RBC) labeling efficiency to an unacceptable level (below 50%.) We have observed an intermittent RBC 99mTc labeling problem in our cardiac transplant patients. After closely examining our in vitro labeling technique and finding no obvious errors, we began to check for a chemical interference from patient medications. We reviewed a detailed list of all medications these transplant patients were taking and felt the immunosuppressant drugs, cyclosporine and Immuran, to be the most suspect. We have currently studied 10 cardiac transplant patients who were undergoing radionuclide ventriculogram (RVG) examinations at our institution. We discovered that peak concentrations of cyclosporine in whole blood of greater than 100 ng/ml significantly decreased RBC labeling efficiency. We found no labeling interference from the other medications, including Immuran.

Footnotes

  • ↵Editor’s note: This manuscript received the second Technologist Award, as selected by the Education and Research (E&R) Foundation of the Society of Nuclear Medicine. The monetary award was made possible by donations to the E&R Foundation.

PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine Technology: 18 (3)
Journal of Nuclear Medicine Technology
Vol. 18, Issue 3
September 1, 1990
  • Table of Contents
  • Index by author
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effects of Cyclosporine in Lowering Red Blood Cell Technetium-99m Labeling Efficiency
(Your Name) has sent you a message from Journal of Nuclear Medicine Technology
(Your Name) thought you would like to see the Journal of Nuclear Medicine Technology web site.
Citation Tools
Effects of Cyclosporine in Lowering Red Blood Cell Technetium-99m Labeling Efficiency
Mel L. Allen, Alan L. McPherson, Bernie J. Mertes, David F. Preston, Ralph G. Robinson
Journal of Nuclear Medicine Technology Sep 1990, 18 (3) 191-193;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Effects of Cyclosporine in Lowering Red Blood Cell Technetium-99m Labeling Efficiency
Mel L. Allen, Alan L. McPherson, Bernie J. Mertes, David F. Preston, Ralph G. Robinson
Journal of Nuclear Medicine Technology Sep 1990, 18 (3) 191-193;
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Early 10-Minute Postinjection [18F]F-FAPI-42 uEXPLORER Total-Body PET/CT Scanning Protocol for Staging Lung Cancer Using HYPER Iterative Reconstruction
  • Single- Versus Dual-Time-Point Imaging for Transthyretin Cardiac Amyloid Using 99mTc-Pyrophosphate
  • Robustness of 18F-FDG PET Radiomic Features in Lung Cancer: Impact of Advanced Reconstruction Algorithm
Show more Imaging

Similar Articles

SNMMI

© 2025 SNMMI

Powered by HighWire