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Nuclear Pharmacy

Dose from Syringe Procedures During Technetium-99m Radiopharmaceutical Preparation

Stanley G. Prussin, George Theofanous, Daniel Casey and Alan Kim
Journal of Nuclear Medicine Technology March 1998, 26 (1) 32-37;
Stanley G. Prussin
Department of Nuclear Engineering, University of California Berkeley and Syncor International Corporation, Berkeley, California
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George Theofanous
Department of Nuclear Engineering, University of California Berkeley and Syncor International Corporation, Berkeley, California
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Daniel Casey
Department of Nuclear Engineering, University of California Berkeley and Syncor International Corporation, Berkeley, California
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Alan Kim
Department of Nuclear Engineering, University of California Berkeley and Syncor International Corporation, Berkeley, California
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Abstract

We examined the dose from 99mTc contained in syringes and shielded vials to assess in detail the dose burdens in a central pharmacy.

Methods: Absorbed-dose rates at the end of the plunger of a shielded syringe, when 99mTc is contained either in the syringe or in a shielded vial from which the activity would be drawn, were measured with CaF2 dosimeters. The dose rates also were calculated with a Monte Carlo model.

Results: When activity was contained in either 3-ml or 10-ml disposable syringes shielded by lead glass, the absorbed-dose rates were 1.35–1.62 mGy hr−1 GBq−1 (5–6 mrad hr−1 mCi−1). When the activity was contained in either a shielded elution or product kit vial, the absorbed-dose rates at the end of the syringe plunger were about 0.40 mGy hr−1 GBq−1 (1.4–1.5 mrad hr−1 mCi−1). These results were reproduced with reasonable accuracy by Monte Carlo simulations.

Conclusion: The dose burden per unit of activity handled from 99mTc in procedures using syringes is likely to be two to five times larger than the dose burden from calibrating generator eluate. The Monte Carlo simulations suggest that lead K x-rays may be responsible for a significant fraction of the total dose to the fingers and hand of the pharmacist when lead-glass syringe shields are used.

  • extremity exposure
  • lead-vial shields
  • lead-glass syringe shields
  • technetium-99m
  • procedures using syringes
  • radiopharmacy
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Journal of Nuclear Medicine Technology: 26 (1)
Journal of Nuclear Medicine Technology
Vol. 26, Issue 1
March 1, 1998
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Dose from Syringe Procedures During Technetium-99m Radiopharmaceutical Preparation
Stanley G. Prussin, George Theofanous, Daniel Casey, Alan Kim
Journal of Nuclear Medicine Technology Mar 1998, 26 (1) 32-37;

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Dose from Syringe Procedures During Technetium-99m Radiopharmaceutical Preparation
Stanley G. Prussin, George Theofanous, Daniel Casey, Alan Kim
Journal of Nuclear Medicine Technology Mar 1998, 26 (1) 32-37;
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  • Evaluation of an Alternative Radiochemical Purity Testing Method for Technetium-99m-Sestamibi
  • Experimental Determination of Dose Calibrator Settings and Study of Associated Volume Dependence in V-Vials for Rhenium-186 Perrhenate Solution Sources
  • The Effect of Vincristine on the Biodistribution of Technetium-99m DTPA, GHA, and DMSA in Balb/c Female Mice
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Keywords

  • extremity exposure
  • lead-vial shields
  • lead-glass syringe shields
  • technetium-99m
  • procedures using syringes
  • radiopharmacy
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