Skip to main content

Main menu

  • Home
  • Content
    • Current
      • JNMT Supplement
    • Ahead of print
    • Past Issues
    • Continuing Education
    • JNMT Podcast
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNMT
    • Information for Authors
    • Assignment of Copyright
    • AQARA Requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNMT
    • JNM
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine Technology
  • SNMMI
    • JNMT
    • JNM
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • Log out
  • My Cart
Journal of Nuclear Medicine Technology

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • Continuing Education
    • JNMT Podcast
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNMT
    • Information for Authors
    • Assignment of Copyright
    • AQARA Requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Watch or Listen to JNMT Podcast
  • Visit SNMMI on Facebook
  • Join SNMMI on LinkedIn
  • Follow SNMMI on Twitter
  • Subscribe to JNMT RSS feeds
Case ReportCASE REPORTS

Post-90Y Radioembolization PET/CT Scan with Respiratory Gating Using Time-of-Flight Reconstruction

Maricon Dizon Mamawan, Seng Chuan Ong and Jonel Marasigan Senupe
Journal of Nuclear Medicine Technology March 2013, 41 (1) 42; DOI: https://doi.org/10.2967/jnmt.112.114413
Maricon Dizon Mamawan
Nuclear Medicine and PET Centre, Mount Elizabeth Hospital, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seng Chuan Ong
Nuclear Medicine and PET Centre, Mount Elizabeth Hospital, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonel Marasigan Senupe
Nuclear Medicine and PET Centre, Mount Elizabeth Hospital, Singapore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Abstract

We present an interesting case of a post-90Y radioembolization PET scan acquired with the aide of respiratory gating. We postulated that respiratory gating would allow accurate tracking of the tumor position, which may be altered by patient breathing. Time-of-flight image reconstruction was used to produce images with less noise in fewer iterations than is possible with conventional PET.

  • respiratory gating
  • 90Y
  • time-of-flight

The internal pair production property of 90Y makes possible its use for imaging by PET (1). Although imaging is impeded by the fact that 90Y is a pure β-emitter, chemically identical surrogates can be used instead (2). In this case, 86Y was the isotope of choice during the scan.

CASE REPORT

A 66-y-old man with hepatocellular carcinoma was radioembolized in the left and right hepatic lobes with 0.4 and 1.4 GBq of 90Y, respectively. Using a 40-slice mCT PET scanner (Biograph; Siemens Medical Solutions) and a respiratory gating hardware system (ANZAI Medical Co., Ltd.), we obtained the PET/CT scan approximately 14 h after 90Y implantation. The CT scan for attenuation correction was obtained at an energy of 120 kV. In total, 86 images (3.0-mm slices) were generated. The CT scan was followed by the PET scan, using 2 bed positions at 10 min each (total scan time, 20 min), aided by respiratory gating with the liver in the field of view. Images were then reconstructed using the TrueX algorithm plus time-of-flight reconstruction (UltraHD PET; Siemens Medical Solutions) with 2 iterations, 21 subsets, and a filter of 2 mm. Post-90Y radioembolization PET/CT showed the microsphere biodistribution in both hepatic lobes (Fig. 1).

FIGURE 1.
  • Download figure
  • Open in new tab
  • Download powerpoint
FIGURE 1.

Right hepatic lobe showing 90Y biodistribution. A color version of this figure is available as a supplemental file at http://tech.snmjournals.org.

DISCUSSION

In this interesting case, a post-90Y radioembolization PET scan was acquired with the aide of respiratory gating. We postulated that respiratory gating would allow accurate tracking of the tumor position despite the movement caused by patient breathing. In addition, time-of-flight image reconstruction was used to produce images with less noise and in fewer iterations than is possible with conventional PET. The biodistribution of microspheres in both hepatic lobes could be visualized.

CONCLUSION

Respiratory gating aided in the accurate tracking of tumor position, and time-of-flight reconstruction provided better images with less noise.

DISCLOSURE

No potential conflict of interest relevant to this article was reported.

Footnotes

  • Published online Jan. 31, 2013.

REFERENCES

  1. 1.↵
    1. Kao YH,
    2. Tan EH,
    3. Lim KY,
    4. Ng CE,
    5. Goh SW
    . Yttrium-90 internal pair production using first generation PET/CT provides high-resolution images for qualitative diagnostic purposes. Br J Radiol. 2012;85:1018–1019.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. Zhu X,
    2. El Fakhri G
    . Monte Carlo modeling of cascade gamma rays in 86Y PET imaging: preliminary results. Phys Med Biol. 2009;54:4181–4193.
    OpenUrlCrossRefPubMed
  • Received for publication September 26, 2012.
  • Accepted for publication January 14, 2013.
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine Technology: 41 (1)
Journal of Nuclear Medicine Technology
Vol. 41, Issue 1
March 1, 2013
  • Table of Contents
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Post-90Y Radioembolization PET/CT Scan with Respiratory Gating Using Time-of-Flight Reconstruction
(Your Name) has sent you a message from Journal of Nuclear Medicine Technology
(Your Name) thought you would like to see the Journal of Nuclear Medicine Technology web site.
Citation Tools
Post-90Y Radioembolization PET/CT Scan with Respiratory Gating Using Time-of-Flight Reconstruction
Maricon Dizon Mamawan, Seng Chuan Ong, Jonel Marasigan Senupe
Journal of Nuclear Medicine Technology Mar 2013, 41 (1) 42; DOI: 10.2967/jnmt.112.114413

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Post-90Y Radioembolization PET/CT Scan with Respiratory Gating Using Time-of-Flight Reconstruction
Maricon Dizon Mamawan, Seng Chuan Ong, Jonel Marasigan Senupe
Journal of Nuclear Medicine Technology Mar 2013, 41 (1) 42; DOI: 10.2967/jnmt.112.114413
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • CASE REPORT
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Improving 90Y PET Scan Image Quality Through Optimized Reconstruction Algorithms
  • Google Scholar

More in this TOC Section

  • Primary Hyperparathyroidism–Related Brown Tumors Mimicking Other Giant Cell–Containing Skeletal Tumors: Role of Correlative Imaging in Diagnosis
  • False-Positive Scalp Activity in 131I Imaging Associated with Hair Coloring
Show more Case Reports

Similar Articles

Keywords

  • respiratory gating
  • 90Y
  • time-of-flight
SNMMI

© 2025 SNMMI

Powered by HighWire