Abstract
Aim: The aim of this study was to estimate and subsequently measure the occupational radiation exposure for all personnel involved in the production, administration, imaging, or surgery with [99mTc]Tc-PSMA-I&S, which has been introduced for identification of tumor-positive lymph nodes during salvage prostate cancer surgery Materials and Methods: The effective dose was estimated and subsequently measured with electronic personal dosimeters for the following procedures and personnel: labeling and quality control by the radiopharmacy technician, syringe preparation by the nuclear medicine laboratory technician, patient administration by the nuclear medicine physician, patient imaging by the nuclear medicine imaging technician, and robot-assisted laparoscopic salvage lymph node dissection attended by an anesthesiology technician, scrub nurse, surgical nurse, and surgeon. The dose rate of the patient was measured immediately after administration of [99mTc]Tc-PSMA-I&S, after imaging, and after surgery. Results: The estimated dose per procedure ranged from 1.59x10-10 µSv (imaging technician) to 9.74 µSv (scrub nurse). The measured effective dose ranged from 0 to 5 µSv for all personnel during one procedure with [99mTc]Tc-PSMA-I&S. The highest effective dose was received by the scrub nurse (3.2±1.3 µSv), whilst the lowest dose was measured for the surgical nurse (0.2±0.5 µSv). If a single scrub nurse would perform as much as 100 procedures with [99mTc]Tc-PSMA-I&S in a year, the total effective dose would be 3.2x10-1 mSv/year. Immediately after administration, the dose rate at 50 cm from the patient was 18.5±1.6 µSv/h, which dropped to 1.8±0.3 µSv/h after imaging the following day and reducing even further to 0.56±0.33 µS/h after surgery. Conclusion: The effective dose for personnel involved in handling [99mTc]Tc-PSMA-I&S is comparable to that of other 99mTc-radiopharmaceuticals and therefore safe for imaging and radioguided surgery.
