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OtherTeaching Case Studies

Antiseptic-Mediated Colloid Labeling as a Potential Source of Abnormal Liver and Spleen Uptake with 99mTc-Dimercaptosuccinic Acid

Veronica Krull, Madison R. Kocher and William J Rieter
Journal of Nuclear Medicine Technology March 2021, jnmt.120.258020; DOI: https://doi.org/10.2967/jnmt.120.258020
Veronica Krull
Medical University of South Carolina, United States
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Madison R. Kocher
Medical University of South Carolina, United States
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William J Rieter
Medical University of South Carolina, United States
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Abstract

Altered biodistribution can be a source of diagnostic error in the interpretation of nuclear medicine studies. We report a case of increased liver and spleen uptake with 99mTc-dimercaptosuccinic acid (DMSA) believed to be a result of chlorhexidine-mediated colloid labeling. This finding underscores the principle that certain constituents of antiseptics may adversely affect the purity of radiopharmaceuticals during their preparation.

  • Quality Assurance
  • Radiopharmaceuticals
  • Renal
  • 99mTc-DMSA
  • antiseptic
  • chlorhexidine
  • colloid
  • liver-spleen
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Journal of Nuclear Medicine Technology: 53 (1)
Journal of Nuclear Medicine Technology
Vol. 53, Issue 1
March 1, 2025
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Antiseptic-Mediated Colloid Labeling as a Potential Source of Abnormal Liver and Spleen Uptake with 99mTc-Dimercaptosuccinic Acid
Veronica Krull, Madison R. Kocher, William J Rieter
Journal of Nuclear Medicine Technology Mar 2021, jnmt.120.258020; DOI: 10.2967/jnmt.120.258020
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Keywords

  • quality assurance
  • radiopharmaceuticals
  • renal
  • 99mTc-DMSA
  • antiseptic
  • chlorhexidine
  • colloid
  • liver-spleen
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Antiseptic-Mediated Colloid Labeling as a Potential Source of Abnormal Liver and Spleen Uptake with 99mTc-Dimercaptosuccinic Acid
Veronica Krull, Madison R. Kocher, William J Rieter
Journal of Nuclear Medicine Technology Mar 2021, jnmt.120.258020; DOI: 10.2967/jnmt.120.258020

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