Aggressive Clinical Course of Dermatofibrosarcoma protuberans: ¹⁸F-FDG PET-CT predictive of Tumor Biology

Abstract

Assessment of tumor biology is an added aspect of molecular imaging with ¹⁸F-FDG PET/CT, which scores over the conventional anatomical imaging in malignancies. An unusual and aggressive case of Dermatofibrosarcoma Protuberans (DFSP) with fatal disease course is presented. In the present case, the high grade ¹⁸F-FDG uptake in the DFSP lesions was predictive of an aggressive disease course in this otherwise indolent behaving entity. The aggressive clinical course was unabated by tyrosine kinase inhibitor imatinib mesylate and the patient showed poor response to this therapy.