^99mTc-HMPAO–Labeled WBC Scan for the Diagnosis of Chronic Recurrent Multifocal Osteomyelitis

Abstract

The goal of this teaching case study is to demonstrate the novel use of ^99mTc-HMPAO-labeled white blood cells (WBCs) in diagnosing chronic recurrent multifocal osteomyelitis (CRMO). ^99mTc-HMPAO-labeled white blood cells were utilized to diagnose CRMO. Classically, CRMO is evaluated scintigraphically using ^99mTc-methylene diphosphonate/hydroxymethylene diphosphonate. ^99mTc-HMPAO-labeled WBCs were chosen over ¹¹¹In-labeled WBCs because of the former's improved imaging characteristics and decreased radiation dose. ^99mTc-HMPAO-labeled WBCs were successful in diagnosing CRMO. ^99mTc-HMPAO-labeled WBC scanning is specific for the diagnosis of CRMO.