Modification of the Schilling Test for Pediatric Studies

Abstract

Distribution of [⁵⁷Co] cyanocobalamin was found to be quite inhomogeneous within the filler of dosing capsules from two manufacturers. Up to 6% of activity was found in or adhering to the capsule wall itself. A volumetric procedure for pediatric Schilling tests is described in which part of a capsule containing [⁵⁷Co] cyanocobalamin is administered.