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Journal of Nuclear Medicine Technology

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Radiopharmacy

Stability of Xenon-127 in Unit Dose Vials

Richard J. Kowalsky
Journal of Nuclear Medicine Technology December 1979, 7 (4) 222-225;
Richard J. Kowalsky
University of North Carolina School of Pharmacy and School of Medicine, Chapel Hill, North Carolina
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Abstract

The stability of Xe-127 in unit dose vials—filled and stored under various conditions—was studied. Vials stored for 40 days retained between 50% and 98% of the original xenon, depending upon the type of rubber closure used. Puncturing the closures during vialfilling had no effect upon retention, with two exceptions. Highest retention was found with synthetic rubber closures and vials stored under refrigeration. Natural rubber closures were unsatisfactory and carrier xenon had little effect upon retarding xenon loss. Vial activity sorbed to rubber closures varied between 1% and 6% and teflon-facing had no effect in retarding xenon loss.

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Journal of Nuclear Medicine Technology: 7 (4)
Journal of Nuclear Medicine Technology
Vol. 7, Issue 4
December 1, 1979
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Stability of Xenon-127 in Unit Dose Vials
Richard J. Kowalsky
Journal of Nuclear Medicine Technology Dec 1979, 7 (4) 222-225;

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Stability of Xenon-127 in Unit Dose Vials
Richard J. Kowalsky
Journal of Nuclear Medicine Technology Dec 1979, 7 (4) 222-225;
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