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Research ArticleContinuing Education

SNMMI Clinical Trials Network Research Series for Technologists: An Introduction to Conducting Theranostic Clinical Trials

Freddy Gonzalez, Peter J.H. Scott, Charlotte Denise Jeffers and S. Cheenu Kappadath
Journal of Nuclear Medicine Technology September 2024, 52 (3) 184-191; DOI: https://doi.org/10.2967/jnmt.123.266588
Freddy Gonzalez
1Department of Diagnostic Imaging, M.D. Anderson Cancer Center, Houston, Texas;
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Peter J.H. Scott
2Department of Radiology, University of Michigan, Ann Arbor, Michigan;
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Charlotte Denise Jeffers
3Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama; and
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S. Cheenu Kappadath
4Department of Imaging Physics, M.D. Anderson Cancer Center, Houston, Texas
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    FIGURE 1.

    Streamlined depiction of common theranostic trial aspects.

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    TABLE 1.

    Investigational Theranostic Clinical Trials List

    Diagnostic radiopharmaceuticalTherapeutic radiopharmaceutical and clinical trial nameSponsorIndicationClinicaltrials.gov identifier
    68Ga-DOTATATE177Lu-DOTATATE (NETTER-2)Novartis PharmaceuticalsSomatostatin tumorsNCT03972488
    68Ga-DOTATATE or 64Cu-DOTATATE225Ac-RYZ101 (ACTION-1)RayzeBioSomatostatin tumorsNCT05477576
    68Ga-DOTATATE177Lu-edotreotide (COMPOSE)ITM Solucin GmbHSomatostatin tumorsNCT04919226
    64Cu-sartate67Cu-sartateClarity Pharmaceuticals Ltd.NeuroblastomaNCT04023331
    68Ga-PSMA-11177Lu-PSMA-617 (PSMAfore)Novartis PharmaceuticalsProstate cancerNCT04689828
    68Ga-PSMA-11177Lu-PSMA-617 (PSMAddition)Novartis PharmaceuticalsProstate cancerNCT04720157
    PSMA agent177Lu-PSMA-I&T (ECLIPSE)Curium US LLCProstate cancerNCT05204927
    68Ga-PSMA-11177Lu-DOTA-rosopatamab (PROSTACT)Telix International Pty Ltd.Prostate cancerNCT04876651
    PSMA agent177Lu-rhPSMA-10.1Blue Earth Therapeutics Ltd.Prostate cancerNCT05413850
    68Ga-PSMA-11225Ac-PSMA-617Telix International Pty Ltd.Prostate cancerNCT04597411
    64Cu-SAR-BBN67Cu-SAR-BBN (COMBAT)Clarity Pharmaceuticals Ltd.Prostate cancerNCT05633160
    68Ga-NeoB177Lu-NeoB (NeoRay)Advanced Accelerator ApplicationsSolid tumorsNCT03872778
    68Ga-DOTATATE177Lu-DOTATATENovartis PharmaceuticalsGlioblastomaNCT05109728
    68Ga-FAP-2286177Lu-FAP-2286 (LuMIERE)Novartis PharmaceuticalsSolid tumorsNCT04939610
    68Ga-DOTA-FAPI177Lu-DOTA-FAPIFirst Affiliated Hospital of Xiamen UniversityVarious cancersNCT04849247
    89Zr-girentuximab177Lu-girentuximabMemorial Sloan Kettering Cancer CenterRenal cancerNCT05239533
    111In-FPI-1547225Ac-FPI-1434Fusion Pharmaceuticals Inc.Solid tumorsNCT03746431
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Journal of Nuclear Medicine Technology: 52 (3)
Journal of Nuclear Medicine Technology
Vol. 52, Issue 3
September 1, 2024
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SNMMI Clinical Trials Network Research Series for Technologists: An Introduction to Conducting Theranostic Clinical Trials
Freddy Gonzalez, Peter J.H. Scott, Charlotte Denise Jeffers, S. Cheenu Kappadath
Journal of Nuclear Medicine Technology Sep 2024, 52 (3) 184-191; DOI: 10.2967/jnmt.123.266588

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SNMMI Clinical Trials Network Research Series for Technologists: An Introduction to Conducting Theranostic Clinical Trials
Freddy Gonzalez, Peter J.H. Scott, Charlotte Denise Jeffers, S. Cheenu Kappadath
Journal of Nuclear Medicine Technology Sep 2024, 52 (3) 184-191; DOI: 10.2967/jnmt.123.266588
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  • Article
    • Abstract
    • REVIEW OF PROTOCOL MANUALS
    • EQUIPMENT QUALIFICATIONS
    • MULTIDISCIPLINARY TEAM LOGISTICS
    • CLINICAL TRIAL ROAD MAP
    • PROTOCOL PLANNING
    • DRUG PREPARATION AND DOSAGE MEASUREMENT
    • INTRAVENOUS ADMINISTRATION METHODS
    • IMAGING DOSIMETRY FOR THE NMT
    • RADIATION SAFETY PRECAUTIONS
    • CONCLUSION
    • DISCLOSURE
    • ACKNOWLEDGMENTS
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Keywords

  • theranostics
  • infusion
  • dosimetry
  • technologist
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