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Journal of Nuclear Medicine Technology

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Research ArticlePractical Protocol Tip

Fatty Meal Hepatobiliary Scintigraphy for Gallbladder Ejection Fraction Determination

Justin G. Peacock and Amanda M. Adams
Journal of Nuclear Medicine Technology March 2024, 52 (1) 21-23; DOI: https://doi.org/10.2967/jnmt.123.266790
Justin G. Peacock
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Amanda M. Adams
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  • FIGURE 1.
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    FIGURE 1.

    Creation of region of interest (ROI) encircling radiopharmaceutical-outlined gallbladder. Ensure that gallbladder remains within ROI throughout post–Ensure Plus dynamic imaging.

  • FIGURE 2.
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    FIGURE 2.

    Time–activity curve for gallbladder ejection fraction, determined from counts within gallbladder ROI throughout course of post–Ensure Plus dynamic imaging. Bkgd = background; EF = ejection fraction; T Max = time of maximum counts/s; T Min = time of minimum counts/s.

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    TABLE 1.

    Radiopharmaceutical Identity, Dose, and Route of Administration

    IdentityDoseRoute of administration
    99mTc-disofenin111 MBq (3 mCi); range, 111–185 MBq (3–5 mCi)Intravenous
    99mTc-mebrofenin111 MBq (3 mCi); range, 111–185 MBq (3–5 mCi)Intravenous
    99mTc-mebrofenin or 99mTc-disofeninPediatric dose: 1.85 MBq/kg (0.05 mCi/kg); minimum, 18.5 MBq (0.5 mCi)Intravenous
    SincalideFor pretreatment, if needed: 0.02 μg/kg over 30–60 min, with infusion completed 15–30 min before radiopharmaceutical administrationIntravenous
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    TABLE 2.

    Dynamic and Static Acquisition Parameters

    ParameterDescriptionStandard, preferred, or optional
    Camera typeLarge field of viewStandard
    Energy peak140 keVStandard
    Energy window20%Standard
    CollimatorLow-energy all-purpose or low-energy high-resolutionStandard
    Patient positionSupineStandard
    Camera positionAnterior with liver in left upper quadrant of field of viewStandard
    Injection-to-imaging timeAcquisition started within 5 min of injectionStandard
    Acquisition typeDynamicStandard
    ViewsAnteriorStandard
    Additional viewsLeft anterior oblique and right lateralOptional
    Matrix128 × 128Standard
    Number of views60Standard
    Frame rate per time1 frame/minPreferred
    Post–Ensure Plus images: 1 frame/30 sStandard
    Additional view time per projection2 minOptional
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Journal of Nuclear Medicine Technology: 52 (1)
Journal of Nuclear Medicine Technology
Vol. 52, Issue 1
March 1, 2024
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Fatty Meal Hepatobiliary Scintigraphy for Gallbladder Ejection Fraction Determination
Justin G. Peacock, Amanda M. Adams
Journal of Nuclear Medicine Technology Mar 2024, 52 (1) 21-23; DOI: 10.2967/jnmt.123.266790

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Fatty Meal Hepatobiliary Scintigraphy for Gallbladder Ejection Fraction Determination
Justin G. Peacock, Amanda M. Adams
Journal of Nuclear Medicine Technology Mar 2024, 52 (1) 21-23; DOI: 10.2967/jnmt.123.266790
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    • RATIONALE/INTRODUCTION
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