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Drug Time frame for withholding Tamoxifen (ER modulator) 8 wk Fulvestrant (ER downregulator) 28 wk - TABLE 2.
Radiopharmaceutical, Recommended Dose, Uptake Time, and PET Scanner Acquisition Time
Radiopharmaceutical Recommended dose Uptake time Acquisition time 18F-fluoroestradiol 222 MBq (6 mCi) (range, 111–222 MBq [3–6 mCi] administered as intravenous injection over 1 to 2 min) 80 min (range, 20–80 min after drug administration) 20–30 min Parameter Description Standard/preferred/optional PET scanner type 2- or 3-dimensional Standard Energy peak 511 keV Standard Energy window 18F-fluorine Standard Patient position Supine with arms above head, if possible Standard Injection-to-scan time 20–80 min after injection Standard 80 min Preferred Acquisition area Whole body (thighs to vertex) Standard Acquisition time 20–30 min Standard Number of bed positions 6–8 Standard Time per bed position 3–4 min/bed Standard For older scanners, increase time per bed position by 30% (i.e., 3 min to 4 min or 5 min to 6.5 min). Standard 18F-FDG whole-body acquisition protocol can be used for WB 18F-fluoroestradiol scan. For PET/CT protocols, refer to manufacturer’s recommendations for CT acquisition parameters.
