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Agent Indication Emission(s) Physical half-life Administered activity 89Sr-chloride Relief of bone pain caused by osseous metastases β, rare γ 50.5 days 148 MBq (4.0 mCi) is recommended; alternative weight-based activity of 1.5-2.2 MBq/kg (40-60 μCi/kg) may be used 153Sm-lexidronam Pain relief in patients with osteoblastic metastases seen on radionuclide bone scan β, γ 1.9 days Weight-based activity of 37 MBq (1.0 mCi) per kg 223Ra-dichloride Treatment of patients with castration-resistant prostate cancer with symptomatic osseous metastases and no known visceral metastatic disease Predominantly α, with additional β and γ 11.4 days Weight-based activity of 55 kBq (1.49 µCi) per kg Organ mGy/MBq rad/mCi Bone surface 17.0 63.0 Red bone marrow 11.0 40.7 Lower bowel wall 4.7 17.4 Bladder wall 1.3 4.8 Testes 0.8 2.9 Ovaries 0.8 2.9 Uterine wall 0.8 2.9 Kidneys 0.8 2.9 Organ mGy/MBq rad/mCi Bone surface 6.8 25.0 Red bone marrow 1.5 5.7 Lower bowel wall 0.01 0.04 Bladder wall 1.0 3.60 Testes 0.01 0.02 Ovaries 0.01 0.03 Kidneys 0.02 0.07 Organ mGy/MBq rad/mCi Osteogenic cells 1152 4263 Red bone marrow 139 514 Lower large intestine wall 46 172 Colon 38 142 Upper large intestine wall 32 120 Urinary bladder wall 4.0 15 Kidneys 3.2 12 Testes 0.08 0.31 Ovaries 0.49 1.8
