Research ArticleImaging

Normative Quantitative Values for Dacryoscintigraphy and the Effect of Lid Massage

Brad Guo, Chong Ghee Chew, Valerie Juniat, Dinesh Selva and Mikayla Dimitri
Journal of Nuclear Medicine Technology June 2023, 51 (2) 147-153; DOI: https://doi.org/10.2967/jnmt.122.265337

Article Figures & Data

Figures

  • Figure
  • FIGURE 1.
    FIGURE 1.

    Example of presac ROI (ROI 1, right eye; ROI 3, left eye) and postsac ROI (ROI 2, right eye; ROI 4, left eye) used in this study. Background correction was subtracted in final quantitative analysis.

  • FIGURE 2.
    FIGURE 2.

    Example of ROI decay-corrected counts presented as scatterplot. (A) Time–activity curve of study with normal clearance on qualitative assessment. (B) Time–activity curve of study with scan appearance of delayed radiotracer clearance.

  • FIGURE 3.
    FIGURE 3.

    (A) Example of dacryoscintigraphy study in our series that demonstrates normal lacrimal system with no regional delay in radiotracer transit. (B) Study that demonstrates bilateral postsac delay. This was interpreted as false-positive study because the participant did not have symptoms of epiphora and had no clinical signs to explain lacrimal system pathology.

  • FIGURE 4.
    FIGURE 4.

    (A) Example of dacryoscintigraphy study in our series that initially demonstrated no nasal radioactivity (arrow) bilaterally. (B) In the same participant, flow of radioactivity into nasal cavity after lid massage. We interpreted this as false-positive study that was averted with lid massage.

Tables

  • TABLE 1.

    Participant Characteristics

    CharacteristicData
    Eyes (n)44
    Age (y)
     Mean71.9 (SD, 9.8)
     Range54–90
    Male (n)14 (63.6%)
  • TABLE 2.

    Comparison of Difference Between Both Eyes of Participants

    ParameterMean difference (min)P
    HCT presac NLM8.140.13
    HCT whole-eye NLM2.200.85
    HCT presac PLM6.760.49
    HCT whole-eye PLM1.250.85
  • TABLE 3.

    Median HCT for Lacrimal Structures

    ParameterNLM (min)PLM (min)P
    HCT presac<0.001
     Median25.571.0
     Interquartile range15.035.5
     Range17–11241–287
    HCT whole eye0.12
     Median40.055.5
     Interquartile range19.533.0
     Range18–19320–225
  • TABLE 4.

    Relationship of HCT with Age and Sex

    ParameterAge (R2)P
    AgeSex
    HCT presac NLM0.010.480.53
    HCT whole-eye NLM0.020.400.29
    HCT presac PLM0.080.080.62
    HCT whole-eye PLM0.010.610.22
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