Skip to main content

Main menu

  • Home
  • Content
    • Current
      • JNMT Supplement
    • Ahead of print
    • Past Issues
    • Continuing Education
    • JNMT Podcast
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNMT
    • Information for Authors
    • Assignment of Copyright
    • AQARA Requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNMT
    • JNM
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine Technology
  • SNMMI
    • JNMT
    • JNM
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine Technology

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • Continuing Education
    • JNMT Podcast
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Rates
    • Journal Claims
    • Institutional and Non-member
  • Authors
    • Submit to JNMT
    • Information for Authors
    • Assignment of Copyright
    • AQARA Requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
    • Corporate & Special Sales
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Watch or Listen to JNMT Podcast
  • Visit SNMMI on Facebook
  • Join SNMMI on LinkedIn
  • Follow SNMMI on Twitter
  • Subscribe to JNMT RSS feeds
Research ArticleBrief Communication

Making the Case for Brain 18F-FDG PET Subtraction in Medically Refractory Epilepsy: A Novel, Useful Tool—Practical Points?

Mehdi Djekidel
Journal of Nuclear Medicine Technology December 2022, 50 (4) 353-356; DOI: https://doi.org/10.2967/jnmt.122.264218
Mehdi Djekidel
QMC, Farmington, Michigan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Additional Files
  • Figure
    • Download figure
    • Open in new tab
    • Download powerpoint
  • FIGURE 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 1.

    Axial (A), coronal (B), and sagittal (C) views of, from left to right, fluid-attenuated inversion recovery MRI, T2-weighted MRI, diffusion-weighted MRI, subtraction 18F-FDG PET fused with T1-weighted MRI, and interictal 18F-FDG PET (in A); ictal 18F-FDG PET (in B); or z score SSP of 18F-FDG PET hypometabolism (in C). Thin white arrows show lesion missed on initial MRI. Thick white arrow shows mild hypometabolism. Yellow arrow shows improved metabolism ictally. Blue arrows show cluster of significance in right Rolandic operculum, corresponding to SOZ.

  • FIGURE 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 2.

    (A) From left to right: 2 basal and left lateral z score SSP views for each of, respectively, preoperative cerebral blood flow 99mTc-hexamethylpropyleneamine oxime SPECT image, postoperative cerebral blood flow 99mTc-hexamethylpropyleneamine oxime SPECT image, and postoperative 18F-FDG PET image. Arrows show 18F-FDG PET hypometabolism, which improved postoperatively. (B) Subtraction preoperative and postoperative 18F-FDG PET/MR images displayed in coronal, sagittal, and 3 axial slices. (C) Subtraction 18F-FDG PET/MR images in all 3 planes showing 2 sites of clusters of significance in left frontal and left parietooccipital lobes. Arrows show 2 potential areas for SOZ. On color scale, yellow-red indicates hypermetabolism and blue-purple indicates hypometabolism.

  • FIGURE 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 3.

    (A) Three-dimensional SSPs showing significant areas of hypometabolism in left occipital lobe interictally. (B) Three-dimensional SSPs showing no areas of hypermetabolism in left occipital lobe ictally or elsewhere; however, severity of hypometabolism in left occipital region has diminished (pseudonormalization of glucose metabolism). (C) Subtraction ictal–interictal 18F-FDG PET/MR image showing cluster of significance in left occipital lobe (SOZ).

  • FIGURE 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    FIGURE 4.

    (A) From left to right: 2 basal and left lateral z score SSP views for each of, respectively, preoperative cerebral blood flow 99mTc-hexamethylpropyleneamine oxime SPECT image, postoperative cerebral blood flow 99mTc-hexamethylpropyleneamine oxime SPECT image, and postoperative 18F-FDG PET image. Arrows show 18F-FDG PET hypometabolism, which improved postoperatively. (B) Subtraction preoperative and postoperative 18F-FDG PET/MR images displayed in coronal, sagittal, and 3 axial slices. (C) Left: intracranial mapping with grid, strip, and depth electrodes; right: z score hypometabolism on preoperative 18F-FDG PET images.

Additional Files

  • Figures
  • Supplemental Data

    Files in this Data Supplement:

    • Supplemental Data
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine Technology: 50 (4)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 4
December 1, 2022
  • Table of Contents
  • About the Cover
  • Index by author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine Technology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Making the Case for Brain 18F-FDG PET Subtraction in Medically Refractory Epilepsy: A Novel, Useful Tool—Practical Points?
(Your Name) has sent you a message from Journal of Nuclear Medicine Technology
(Your Name) thought you would like to see the Journal of Nuclear Medicine Technology web site.
Citation Tools
Making the Case for Brain 18F-FDG PET Subtraction in Medically Refractory Epilepsy: A Novel, Useful Tool—Practical Points?
Mehdi Djekidel
Journal of Nuclear Medicine Technology Dec 2022, 50 (4) 353-356; DOI: 10.2967/jnmt.122.264218

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Making the Case for Brain 18F-FDG PET Subtraction in Medically Refractory Epilepsy: A Novel, Useful Tool—Practical Points?
Mehdi Djekidel
Journal of Nuclear Medicine Technology Dec 2022, 50 (4) 353-356; DOI: 10.2967/jnmt.122.264218
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Visual Abstract
    • Abstract
    • CASE PRESENTATION 1
    • CASE PRESENTATION 2
    • CASE PRESENTATION 3
    • CASE PRESENTATION 4
    • CONCLUSION
    • DISCLOSURE
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Five Years in Review
  • Google Scholar

More in this TOC Section

  • Patient Motion During Cardiac PET Imaging
  • Fitness for Purpose of Text-to-Image Generative Artificial Intelligence Image Creation in Medical Imaging
  • Logistics of Adopting 177Lu-Vipivotide Tetraxetan Therapy in a Community-Based Hospital Setting
Show more Brief Communication

Similar Articles

Keywords

  • brain PET
  • FDG
  • epilepsy
  • subtraction PET
SNMMI

© 2025 SNMMI

Powered by HighWire