Stability Matters: Radiochemical Stability of Therapeutic Radiopharmaceutical 177Lu-PSMA I&amp;T

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
Download figure
Open in new tab
Download powerpoint
FIGURE 1.
Modular-Lab Pharm cassettes supplied by Eckert and Ziegler.
Download figure
Open in new tab
Download powerpoint
FIGURE 2.
A line graph showing HPLC quality control result comparison at 0, 24, and 48 h.
Download figure
Open in new tab
Download powerpoint
FIGURE 3.
A line graph showing ITLC-SG quality control result comparison at 0, 24, and 48 h.
Download figure
Open in new tab
Download powerpoint
FIGURE 4.
A line graph showing result of HPLC and ITLC-SG at 0 and 48 h.

TABLE 1.

HPLC Results at Various Times

Batch no.	HPLC purity result at 0 h	HPLC purity result at 24 h	HPLC purity result at 48 h
1	99.78	99.7	99.7
2	99.75	99.87	99.75
3	99.56	99.5	99.65
4	99.89	99.8	99.89
5	99.91	99.91	99.95
6	99.92	99.92	99.92
7	99.98	99.98	99.98
8	99.87	99.87	99.87
9	99.76	99.76	99.76
10	99.56	99.56	99.56
11	99.6	99.6	99.75
12	99.76	99.76	99.76
13	99.8	99.8	99.8
14	99.45	99.45	99.45
15	99.13	99.13	99.13
16	99.35	99.35	99.35
17	99.56	99.56	99.56
18	99.87	99.87	99.87
19	99.74	99.74	99.74
20	99.15	99.15	99.15
21	99.3	99.3	99.3
22	98.9	98.9	98.9
23	99.56	99.56	99.56
24	99.45	99.45	99.45
25	99.57	99.57	99.6
26	99.45	99.45	99.55
27	99.87	99.87	99.77
28	99.67	99.7	99.67
29	99.78	99.78	99.78
30	99.55	99.55	99.55
31	99.65	99.65	99.75
32	99.15	99.2	99.15
33	99.45	99.45	99.45
34	99.5	99.65	99.5
35	99.75	99.75	99.7

TABLE 2.

ITLC-SG Results at Various Times

Batch no.	TLC purity result at 0 h	TLLC purity result at 24 h	TLC purity result at 48 h
1	99.70	99.7	99.7
2	99.65	99.87	99.75
3	99.76	99.5	99.65
4	99.95	99.8	99.89
5	99.97	99.91	99.95
6	99.95	99.92	99.92
7	99.98	99.98	99.98
8	99.97	99.87	99.87
9	99.98	99.76	99.76
10	99.66	99.56	99.56
11	99.60	99.6	99.75
12	99.76	99.76	99.76
13	99.80	99.8	99.8
14	98.67	99.45	99.45
15	98.76	99.13	99.13
16	99.76	99.35	99.35
17	99.56	99.56	99.56
18	99.87	99.87	99.87
19	99.65	99.74	99.74
20	99.15	99.15	99.15
21	99.35	99.3	99.3
22	98.91	98.9	98.9
23	99.65	99.56	99.56
24	99.45	99.45	99.45
25	99.57	99.57	99.6
26	99.45	99.45	99.55
27	99.77	99.87	99.77
28	99.67	99.7	99.67
29	99.78	99.78	99.77
30	99.55	99.55	99.55
31	99.65	99.65	99.75
32	99.25	99.2	99.45
33	99.45	99.45	99.45
34	99.65	99.65	99.55
35	99.75	99.75	99.67