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Research ArticleBasic Science Investigation

Stability Matters: Radiochemical Stability of Therapeutic Radiopharmaceutical 177Lu-PSMA I&T

Madhusudan Vyas, Remy Lim, Jessica Fagan and Rudresh Chandrashekar
Journal of Nuclear Medicine Technology September 2022, 50 (3) 244-247; DOI: https://doi.org/10.2967/jnmt.121.262423
Madhusudan Vyas
1Department of Nuclear Medicine and PET-CT, Mercy Radiology, Auckland, New Zealand; and
2School of Healthcare and Social Practice, Unitec Institute of Technology, Auckland, New Zealand
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Remy Lim
1Department of Nuclear Medicine and PET-CT, Mercy Radiology, Auckland, New Zealand; and
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Jessica Fagan
1Department of Nuclear Medicine and PET-CT, Mercy Radiology, Auckland, New Zealand; and
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Rudresh Chandrashekar
1Department of Nuclear Medicine and PET-CT, Mercy Radiology, Auckland, New Zealand; and
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  • FIGURE 1.
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    FIGURE 1.

    Modular-Lab Pharm cassettes supplied by Eckert and Ziegler.

  • FIGURE 2.
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    FIGURE 2.

    A line graph showing HPLC quality control result comparison at 0, 24, and 48 h.

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    FIGURE 3.

    A line graph showing ITLC-SG quality control result comparison at 0, 24, and 48 h.

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    FIGURE 4.

    A line graph showing result of HPLC and ITLC-SG at 0 and 48 h.

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    TABLE 1.

    HPLC Results at Various Times

    Batch no.HPLC purity result at 0 hHPLC purity result at 24 hHPLC purity result at 48 h
    199.7899.799.7
    299.7599.8799.75
    399.5699.599.65
    499.8999.899.89
    599.9199.9199.95
    699.9299.9299.92
    799.9899.9899.98
    899.8799.8799.87
    999.7699.7699.76
    1099.5699.5699.56
    1199.699.699.75
    1299.7699.7699.76
    1399.899.899.8
    1499.4599.4599.45
    1599.1399.1399.13
    1699.3599.3599.35
    1799.5699.5699.56
    1899.8799.8799.87
    1999.7499.7499.74
    2099.1599.1599.15
    2199.399.399.3
    2298.998.998.9
    2399.5699.5699.56
    2499.4599.4599.45
    2599.5799.5799.6
    2699.4599.4599.55
    2799.8799.8799.77
    2899.6799.799.67
    2999.7899.7899.78
    3099.5599.5599.55
    3199.6599.6599.75
    3299.1599.299.15
    3399.4599.4599.45
    3499.599.6599.5
    3599.7599.7599.7
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    TABLE 2.

    ITLC-SG Results at Various Times

    Batch no.TLC purity result at 0 hTLLC purity result at 24 hTLC purity result at 48 h
    199.7099.799.7
    299.6599.8799.75
    399.7699.599.65
    499.9599.899.89
    599.9799.9199.95
    699.9599.9299.92
    799.9899.9899.98
    899.9799.8799.87
    999.9899.7699.76
    1099.6699.5699.56
    1199.6099.699.75
    1299.7699.7699.76
    1399.8099.899.8
    1498.6799.4599.45
    1598.7699.1399.13
    1699.7699.3599.35
    1799.5699.5699.56
    1899.8799.8799.87
    1999.6599.7499.74
    2099.1599.1599.15
    2199.3599.399.3
    2298.9198.998.9
    2399.6599.5699.56
    2499.4599.4599.45
    2599.5799.5799.6
    2699.4599.4599.55
    2799.7799.8799.77
    2899.6799.799.67
    2999.7899.7899.77
    3099.5599.5599.55
    3199.6599.6599.75
    3299.2599.299.45
    3399.4599.4599.45
    3499.6599.6599.55
    3599.7599.7599.67

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Journal of Nuclear Medicine Technology: 50 (3)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 3
September 1, 2022
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Stability Matters: Radiochemical Stability of Therapeutic Radiopharmaceutical 177Lu-PSMA I&T
Madhusudan Vyas, Remy Lim, Jessica Fagan, Rudresh Chandrashekar
Journal of Nuclear Medicine Technology Sep 2022, 50 (3) 244-247; DOI: 10.2967/jnmt.121.262423

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Stability Matters: Radiochemical Stability of Therapeutic Radiopharmaceutical 177Lu-PSMA I&T
Madhusudan Vyas, Remy Lim, Jessica Fagan, Rudresh Chandrashekar
Journal of Nuclear Medicine Technology Sep 2022, 50 (3) 244-247; DOI: 10.2967/jnmt.121.262423
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Keywords

  • quality assurance
  • radiochemistry
  • Radionuclide Therapy
  • high-performance liquid chromatography (HPLC)
  • instant thin-layer chromatography (ITLC)
  • lutetium-177 (Lu177)
  • prostate-specific membrane antigen image and therapy (PSMA)
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