PET/CT in the Evaluation of Hypoxia for Radiotherapy Planning in Head and Neck Tumors: Systematic Literature Review

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
FIGURE 1.
Flowchart of inclusion and exclusion of bibliographic references.

TABLE 1

Incidence and Mortality Rate of Head and Neck Tumors (14)

TABLE 2

Analysis of the Radiopharmaceuticals Used in PET/CT to Evaluate Hypoxic Cells

	Articles mentioning…
Tracer	Head andneck tumors	Lipophilic/hydrophilic	LogP	Radiopharmaceuticalsensitive to acute hypoxiadetection	Image acquisitiontime after administration	SUV	Nonhypoxic cell clearance velocity	Reproducibility ofradiopharmaceutical	Excretionroute
¹⁸F-FMISO	(23,29,35,44,48)	Lipophilic(23,24,29)	-0.42 to −0.38 (50)	None	2–4 h(9,20,23,35,51)	None	↓ (51)	None	Hepatobiliary and gastrointestinal (50)
¹⁸F-FETNIM	(29,44)	Hydrophilic (24,38)	None	None	None	None	↑ (20)	None	Rapid renal and low hepatic (24,38)
¹⁸F-FAZA	(29,44)	Hydrophilic (24,29)	0.04 (50)	(27)	2–3 h (18,27)	↑ (54)	↑ (4,29,54)	None	None
¹⁸F-HX4	(29)	Hydrophilic (24,29)	−0.71 to −0.67 (50)	(27)	1.5–4 h (18,27)	None	↑ (50)	None	Intestinal, low hepatic.mostly renal (24,38,50)
¹⁸F-RP-170	None	None	None	None	None	↑ (24)	None	None	None
¹⁸F-FPIMO	None	None	None	None	None	↓ (54)	None	None	Hepatic and renal (54)
¹⁸F-EF5	(29 , 56)	Lipophilic (20,24)	None	None	3 h (56)	None	None	↑ (17)	None
⁶²Cu-ATSM	(29)	Neutral lipophilic (41,43)	None	None	10–15 min(40,41)	None	↑ (41–43)	None	None
⁶⁴Cu-ATSM	(29)	Neutral lipophilic (20,24)	None	None	10–15 min (20,24)	None	↑ (29,38)	None	Reduced renal (high liver accumulation) (58)